Clarke H M, Howard C R, Pynn B R, McKee N H
Plast Reconstr Surg. 1985 Apr;75(4):560-4. doi: 10.1097/00006534-198504000-00021.
A model for the study of neovascularization with a normal epigastric free flap set into an irradiated defect in the Fischer F344 rat is presented. In this model, both the administration of radiation and the flap transfer mimic the clinical situation. Significantly less tissue survives loss of the complete vascular pedicle at the second to fourth days following flap creation in rats with an irradiated bed. Later survival is not different from controls. Delayed neovascularization is proposed as the mechanism responsible for this effect during the period corresponding to the onset of the late phase of the response to skin radiation in rats. That neovascularization does occur, although delayed, suggests that the induced endarteritis may not be as important as previously suggested.
本文介绍了一种在Fischer F344大鼠中将正常腹壁游离皮瓣植入受辐照缺损处用于研究新生血管形成的模型。在该模型中，放射治疗和皮瓣转移均模拟了临床情况。在受辐照创面的大鼠中，皮瓣形成后第二至四天，完整血管蒂丧失时存活的组织明显减少。后期存活率与对照组无差异。延迟新生血管形成被认为是在大鼠皮肤辐射反应后期开始的这段时间内造成这种影响的机制。尽管新生血管形成延迟，但确实发生了，这表明诱导性动脉内膜炎可能没有先前认为的那么重要。
