Leocádio Paola C L, Antunes Maísa M, Teixeira Lílian G, Leonel Alda J, Alvarez-Leite Jacqueline I, Machado Denise C C, Generoso Simone V, Cardoso Valbert N, Correia Maria Isabel T D
a Postgraduate Program in Food Science , Faculty of Pharmacy, UFMG , Belo Horizonte , MG , Brazil.
Nutr Cancer. 2015;67(3):486-93. doi: 10.1080/01635581.2015.1004730. Epub 2015 Mar 24.
Beneficial effects of L-arginine on immune responses and bowel function have been reported. Mucositis is a side effect of chemotherapy treatment that affects approximately 40% of patients. This complication is characterized by inflammation that affects the gastrointestinal tract, increasing permeability and causing abdominal pain, nausea, vomiting, and diarrhea, which worsen the patient's nutritional status and increases morbimortality. The aim of this study was to evaluate the effect of pretreating with 2% L-arginine supplementation in water on mucositis as induced by 5-fluorouracil (5-FU; a single dose of 200 mg/kg body weight) in Swiss male mice. The effect of L-arginine on weight, intestinal permeability, morphology, and the histopathological score of the small intestine (from 0 to 12), oxidative stress, myeloperoxidase (MPO), and N-acetylglucosaminidase (NAG) activities were evaluated. Intestinal length improvement was observed, in addition to the partial recovery of the mucosal architecture. L-arginine attenuated the histopathological score and MPO activity. There was also an improvement in intestinal permeability, despite weight loss after 5-FU administration. In conclusion, L-arginine can positively impact intestinal mucositis by promoting partial mucosal recovery, reducing inflammation and improving intestinal permeability.
已有报道称L-精氨酸对免疫反应和肠道功能具有有益作用。黏膜炎是化疗治疗的一种副作用，约40%的患者会受到影响。这种并发症的特征是炎症影响胃肠道，增加通透性并导致腹痛、恶心、呕吐和腹泻，从而使患者的营养状况恶化并增加病死 率。本研究的目的是评估在瑞士雄性小鼠中，预先用含2% L-精氨酸的水进行预处理对5-氟尿嘧啶（5-FU；单剂量200 mg/kg体重）诱导的黏膜炎的影响。评估了L-精氨酸对体重、肠道通透性、形态以及小肠组织病理学评分（0至12分）、氧化应激、髓过氧化物酶（MPO）和N-乙酰葡糖胺酶（NAG）活性的影响。除了黏膜结构部分恢复外，还观察到肠长度增加。L-精氨酸降低了组织病理学评分和MPO活性。尽管给予5-FU后体重有所下降，但肠道通透性也有所改善。总之，L-精氨酸可通过促进黏膜部分恢复、减轻炎症和改善肠道通透性，对肠道黏膜炎产生积极影响。
