Pritchett T R, Skinner D G, Selser S F, Kern W H
Urology. 1985 Apr;25(4):344-6. doi: 10.1016/0090-4295(85)90482-0.
An elevated serum level of human chorionic gonadotropin (HCG) in a patient whose primary tumor histologically appears to be a pure seminoma implies the presence of syncytiotrophoblastic giant cells either detectable by careful step sectioning of the primary tumor or present in metastatic disease. Inasmuch as the malignant potential and radioresponsiveness of syncytiotrophoblastic giant cells are unknown and the serum elevation of HCG may signal metastatic embryonal carcinoma, retroperitoneal lymph node dissection with adjuvant chemotherapy dependent on pathologic staging should be considered for patients with seminoma and postorchiectomy elevated HCG levels. An illustrative case is herein reported.
对于原发性肿瘤组织学上看似为纯精原细胞瘤的患者，血清人绒毛膜促性腺激素（HCG）水平升高意味着存在合体滋养层巨细胞，这可通过对原发性肿瘤进行仔细的连续切片检测到，或存在于转移性疾病中。由于合体滋养层巨细胞的恶性潜能和放射反应性尚不清楚，且血清HCG升高可能提示转移性胚胎癌，对于精原细胞瘤且睾丸切除术后HCG水平升高的患者，应考虑根据病理分期进行腹膜后淋巴结清扫及辅助化疗。本文报告了一个说明性病例。
