Kogel H, Grundmann R, Fohlmeister I, Pichlmaier H
Zentralbl Chir. 1985;110(2-3):147-54.
On the basis of experimental studies carried out in animals several authors could demonstrate that cryotherapy is able to induce a raise of auto- and tumour-antibodies. The specificity of these reactions has been proved. Comparative analysis could verify greater immune response after 'in situ-destruction' of tumours than after conventional surgical excision. In 13 patients cryosurgically treated for inoperable rectal carcinoma a raised concentration of IgG and IgA could be shown in several patients in the area surrounding the carcinomatous cells by means of a direct immune fluorescent technique in biopsies of the tumour. Immune globulines of the class IgA seemed to be important. Our results suggest a probable correlation of immune response and clinical course. The prognostic value of our method has to be examined in a larger group of patients and laboratory experiments. Cryotherapy can be regarded as one of several possible forms of treatment to brake the barrier of immunity in cancer patients.
基于在动物身上进行的实验研究，几位作者能够证明冷冻疗法能够诱导自身抗体和肿瘤抗体的增加。这些反应的特异性已经得到证实。比较分析可以验证，肿瘤“原位破坏”后比传统手术切除后的免疫反应更强。在13例接受冷冻手术治疗的无法手术切除的直肠癌患者中，通过肿瘤活检的直接免疫荧光技术，在癌细胞周围区域的几名患者中显示出IgG和IgA浓度升高。IgA类免疫球蛋白似乎很重要。我们的结果表明免疫反应与临床病程可能存在相关性。我们方法的预后价值必须在更大规模的患者群体和实验室实验中进行检验。冷冻疗法可被视为打破癌症患者免疫屏障的几种可能治疗形式之一。
