Gardó S, Wessely J
Zentralbl Gynakol. 1985;107(1):31-4.
In 1000 singleton pregnancies between 16 and 18 weeks maternal serum alpha-fetoprotein (AFP) levels were related to maternal weight. The heavier women had lower mean levels apparently as a result of the diluting effect of larger blood volume. Lighter women had higher AFP levels, perhaps on account of the greater concentration of AFP in their relatively smaller volume of blood. A policy of evaluating the maternal serum AFP level according to maternal weight among women with borderline positive results could reduce both the number of patients having a diagnostic amniocentesis, and the rate of false negative cases.
在1000例孕16至18周的单胎妊娠中，孕妇血清甲胎蛋白（AFP）水平与孕妇体重相关。体重较重的女性平均水平较低，这显然是由于血容量较大产生的稀释作用。体重较轻的女性AFP水平较高，可能是因为她们相对较少的血容量中AFP浓度较高。对于临界阳性结果的女性，根据孕妇体重评估孕妇血清AFP水平的策略可以减少接受诊断性羊膜穿刺术的患者数量以及假阴性病例的发生率。
