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Loss of Klotho in CKD Breaks One's Heart.

作者信息

Fu Haiyan, Liu Youhua

机构信息

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China; and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

出版信息

J Am Soc Nephrol. 2015 Oct;26(10):2305-7. doi: 10.1681/ASN.2015020200. Epub 2015 Mar 24.

DOI:10.1681/ASN.2015020200
PMID:25804282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4587709/
Abstract
摘要

相似文献

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Loss of Klotho in CKD Breaks One's Heart.慢性肾脏病中klotho蛋白缺失令人痛心。
J Am Soc Nephrol. 2015 Oct;26(10):2305-7. doi: 10.1681/ASN.2015020200. Epub 2015 Mar 24.
2
Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy.α-klotho蛋白可预防硫酸吲哚酚诱导的心肌肥大。
J Am Soc Nephrol. 2015 Oct;26(10):2434-46. doi: 10.1681/ASN.2014060543. Epub 2015 Mar 24.
3
The FGF23-Klotho axis and cardiac tissue Doppler imaging in pediatric chronic kidney disease-a prospective cohort study.成纤维细胞生长因子 23-klotho 轴与儿科慢性肾脏病患儿的组织多普勒超声心动图：一项前瞻性队列研究。
Pediatr Nephrol. 2018 Jan;33(1):147-157. doi: 10.1007/s00467-017-3766-5. Epub 2017 Aug 9.
4
[Role of the morphogenetic proteins FGF-23 and Klotho and the glycoprotein sclerostin in the assessment of the risk of cardiovascular diseases and the prognosis of chronic kidney disease].[形态发生蛋白FGF-23和Klotho以及糖蛋白硬化蛋白在评估心血管疾病风险和慢性肾脏病预后中的作用]
Ter Arkh. 2015;87(6):10-16. doi: 10.17116/terarkh201587610-16.
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Association between FGF23, α-Klotho, and Cardiac Abnormalities among Patients with Various Chronic Kidney Disease Stages.不同慢性肾脏病阶段患者中FGF23、α-klotho与心脏异常之间的关联
PLoS One. 2016 Jul 11;11(7):e0156860. doi: 10.1371/journal.pone.0156860. eCollection 2016.
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Transplant Proc. 2014 Nov;46(9):3194-8. doi: 10.1016/j.transproceed.2014.10.034.

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Medicine (Baltimore). 2024 Nov 22;103(47):e40577. doi: 10.1097/MD.0000000000040577.
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Klotho-derived peptide KP1 ameliorates SARS-CoV-2-associated acute kidney injury.α-klotho衍生肽KP1可改善SARS-CoV-2相关的急性肾损伤。
Front Pharmacol. 2024 Jan 3;14:1333389. doi: 10.3389/fphar.2023.1333389. eCollection 2023.
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Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome.Wnt/β-catenin 信号通路介导 2 型心肾综合征中心脏和肾脏损伤。
Kidney Int. 2019 Apr;95(4):815-829. doi: 10.1016/j.kint.2018.11.021. Epub 2019 Feb 12.
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Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression.肿瘤进展过程中TGF-β1信号负调控的失调
Cancers (Basel). 2018 May 25;10(6):159. doi: 10.3390/cancers10060159.
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The role of fibroblast growth factor 23 and Klotho in uremic cardiomyopathy.成纤维细胞生长因子23和α-klotho在尿毒症心肌病中的作用。
Curr Opin Nephrol Hypertens. 2016 Jul;25(4):314-24. doi: 10.1097/MNH.0000000000000231.

本文引用的文献

1
Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy.α-klotho蛋白可预防硫酸吲哚酚诱导的心肌肥大。
J Am Soc Nephrol. 2015 Oct;26(10):2434-46. doi: 10.1681/ASN.2014060543. Epub 2015 Mar 24.
2
Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate.可溶性α-klotho独立于成纤维细胞生长因子23和磷酸盐预防尿毒症心肌病。
J Am Soc Nephrol. 2015 May;26(5):1150-60. doi: 10.1681/ASN.2014040325. Epub 2014 Dec 4.
3
Klotho suppresses renal tubulo-interstitial fibrosis by controlling basic fibroblast growth factor-2 signalling.α-klotho通过控制碱性成纤维细胞生长因子-2信号传导来抑制肾小管间质纤维化。
J Pathol. 2014 Dec;234(4):560-72. doi: 10.1002/path.4420. Epub 2014 Sep 30.
4
Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling.肾素-血管紧张素系统的多个基因是 Wnt/β-连环蛋白信号的新靶点。
J Am Soc Nephrol. 2015 Jan;26(1):107-20. doi: 10.1681/ASN.2014010085. Epub 2014 Jul 10.
5
The kidney is the principal organ mediating klotho effects.肾脏是介导klotho效应的主要器官。
J Am Soc Nephrol. 2014 Oct;25(10):2169-75. doi: 10.1681/ASN.2013111209. Epub 2014 May 22.
6
Targeting protein-bound uremic toxins in chronic kidney disease.靶向慢性肾脏病中的蛋白结合型尿毒症毒素。
Expert Opin Ther Targets. 2013 Nov;17(11):1287-301. doi: 10.1517/14728222.2013.829456. Epub 2013 Aug 13.
7
Cardiorenal syndrome type 4: insights on clinical presentation and pathophysiology from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI).4型心肾综合征：急性透析质量倡议（ADQI）第十一次共识会议对临床表现和病理生理学的见解
Contrib Nephrol. 2013;182:158-73. doi: 10.1159/000349972. Epub 2013 May 13.
8
Klotho and chronic kidney disease.α-klotho与慢性肾脏病
Contrib Nephrol. 2013;180:47-63. doi: 10.1159/000346778. Epub 2013 May 3.
9
Loss of Klotho contributes to kidney injury by derepression of Wnt/β-catenin signaling.Klotho 的缺失通过解除 Wnt/β-连环蛋白信号通路的抑制作用导致肾脏损伤。
J Am Soc Nephrol. 2013 Apr;24(5):771-85. doi: 10.1681/ASN.2012080865. Epub 2013 Apr 4.
10
Klotho in health and disease.Klotho 在健康与疾病中的作用。
Curr Opin Nephrol Hypertens. 2012 Jul;21(4):362-8. doi: 10.1097/MNH.0b013e32835422ad.