来自圆锥花钟藤叶子的三萜糖苷类化合物两性花钟藤苷A - D以及脂肪醇糖苷类化合物两性花钟藤苷E。

Amphipaniculosides A-D, triterpenoid glycosides, and amphipaniculoside E, an aliphatic alcohol glycoside from the leaves of Amphilophium paniculatum.

作者信息

Samy Mamdouh Nabil, Khalil Hany Ezzat, Sugimoto Sachiko, Matsunami Katsuyoshi, Otsuka Hideaki, Kamel Mohamed Salah

机构信息

Department of Pharmacognosy, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

出版信息

Phytochemistry. 2015 Jul;115:261-8. doi: 10.1016/j.phytochem.2015.02.020. Epub 2015 Mar 21.

DOI:10.1016/j.phytochem.2015.02.020

PMID:25804328

Abstract

Four new triterpenoids; One oleanane-, one ursane- and two cycloartane-type triterpenoids, named amphipaniculosides A-D, in addition to one new aliphatic alcohol glycoside, named amphipaniculoside E, were isolated from the 1-BuOH fraction of the leaves of Amphilophium paniculatum (L.) Kunth., together with five known compounds, (+)-lyoniresinol 3α-O-β-D-glucopyranoside, (-)-lyoniresinol 3α-O-β-D-glucopyranoside, acteoside (verbascoside), isoacteoside (isoverbascoside), and luteolin 7-O-β-D-glucopyranoside. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments ((1)H, (13)C, DEPT, COSY, ROESY, HSQC, HMBC) in combination with HR-ESI-MS and by comparisons of their physical and spectroscopic data with literature values.

摘要

从圆锥花大萼距花（Amphilophium paniculatum (L.) Kunth.）叶片的正丁醇萃取物中，分离得到了四种新的三萜类化合物，即一个齐墩果烷型、一个乌苏烷型和两个环阿尔廷烷型三萜类化合物，命名为双圆锥花苷A - D，此外还得到了一种新的脂肪醇糖苷，命名为双圆锥花苷E，同时还分离出了五种已知化合物，分别为(+)-裂环马钱子苷3α - O - β - D - 吡喃葡萄糖苷、(-)-裂环马钱子苷3α - O - β - D - 吡喃葡萄糖苷、洋地黄苷（毛蕊花糖苷）、异洋地黄苷（异毛蕊花糖苷）和木犀草素7 - O - β - D - 吡喃葡萄糖苷。通过包括一维和二维核磁共振实验（(1)H、(13)C、DEPT、COSY、ROESY、HSQC、HMBC）在内的光谱方法，结合高分辨电喷雾电离质谱，并将其物理和光谱数据与文献值进行比较，确定了它们的结构。