Amir I, Vernham G A
Department of Otolaryngology and Head and Neck Surgery,NHS Lothian,Edinburgh,Scotland, UK.
J Laryngol Otol. 2015 Apr;129(4):372-6. doi: 10.1017/S0022215115000626. Epub 2015 Mar 25.
This study aimed to report our current practice of transoral laser microsurgery for early glottic cancer against the standards outlined by the ENT UK Head and Neck Group and assess the oncological outcome.
A retrospective review of case notes of patients diagnosed with early glottic cancer (tumour stages Tis, T1 and T2) who underwent transoral laser microsurgery as a primary curative treatment. The minimum follow-up period was two years.
Thirty-one patients had transoral laser microsurgery for early glottic cancer during the study period. Eighty-four per cent of cases were discussed by a multidisciplinary team prior to transoral laser microsurgery. Complete circumferential excision was achieved in 77 per cent of cases. Sixty-five per cent of specimens were subjected to histological analysis; they complied with standard pathology reporting for margins. Within 12 months of transoral laser microsurgery, there were 10 residual cases and 2 recurrences. Kaplan-Meier survival analysis gave disease-free survival rates of 96.8 per cent at 18 months and 93.5 per cent at 24 months. The laryngectomy-free survival rate was 96.8 per cent at two years.
The findings of this audit are encouraging and have highlighted areas for further discussions, recommendations, training and education.
本研究旨在报告我们目前针对早期声门癌的经口激光显微手术实践,对照英国耳鼻喉科头颈组制定的标准进行评估,并评估肿瘤学结局。
对诊断为早期声门癌(肿瘤分期为Tis、T1和T2)且接受经口激光显微手术作为主要根治性治疗的患者病历进行回顾性研究。最短随访期为两年。
在研究期间,31例患者接受了早期声门癌的经口激光显微手术。84%的病例在经口激光显微手术前由多学科团队进行了讨论。77%的病例实现了完整的环周切除。65%的标本进行了组织学分析;它们符合切缘的标准病理报告。在经口激光显微手术后12个月内,有10例残留病例和2例复发。Kaplan-Meier生存分析得出18个月时无病生存率为96.8%,24个月时为93.5%。两年时无喉切除术生存率为96.8%。
本次审核结果令人鼓舞,并突出了有待进一步讨论、建议、培训和教育的领域。