Köckerling F, Bittner R, Jacob D A, Seidelmann L, Keller T, Adolf D, Kraft B, Kuthe A
Department of Surgery and Center for Minimally Invasive Surgery, Academic Teaching Hospital of Charité Medical School, Vivantes Hospital, Neue Bergstraße 6, 13585, Berlin, Germany.
Hernia Center, Winghofer Medicum, Winghofer Straße 42, 72108, Rottenburg am Neckar, Germany.
Surg Endosc. 2015 Dec;29(12):3750-60. doi: 10.1007/s00464-015-4150-9. Epub 2015 Mar 25.
More than 20 years since the introduction of TAPP and TEP into clinical routine, there is a lack of clarity due to conflicting comparative data. Therefore, more results from registries are needed.
A total of 17,587 patients were enrolled prospectively between September 1, 2009, and April 15, 2013, in the Herniamed registry. Of these patients, 10,887 (61.9%) had a TAPP and 6700 (38.1%) a TEP repair. The dependent variables were intra- and postoperative complication rates, number of reoperations as well as absolute and relative frequencies. The results of unadjusted analyses were verified via multivariable analyses.
Multivariable analysis verified the results of unadjusted analysis, indicating that the surgical technique did not have any significant impact, also while taking account of other factors, on occurrence of intraoperative [p = 0.1648; OR = 1.214 (0.923; 1.596)] and general postoperative complications [p = 0.0738; OR = 1.315 (0.974; 1.775)]. Postoperative surgical complications [OR = 2.323 (1.882; 2.866); p < 0.0001] were noted more often after TAPP. Furthermore, the hernia defect size [p < 0.0001; I vs III: OR = 0.439 (0.313; 0.615), II vs III: OR = 0.712 (0.582; 0.872)] or scrotal [p < 0.0001; OR = 2.170 (1.501; 3.137)] hernia and age [p = 0.0002; 10-year OR = 1.135 (1.062; 1.213)] had a significant impact on the occurrence of postoperative complications. Complications were observed more commonly for larger hernia defects and a scrotal hernia. However, the difference in the postoperative complication rate between TEP and TAPP did not result in any difference in the reoperation rate (TEP 0.82% vs TAPP 0.90%; p = 0.6165).
The intraoperative and general postoperative complication rates as well as the reoperation rate for complications show no significant difference between TEP and TAPP. The higher postoperative complication rate for TAPP, which could be managed conservatively, is partly explained by larger defect sizes, more scrotal hernias and older age.
自TAPP和TEP引入临床常规操作已有20多年,但由于对比数据相互矛盾,目前仍缺乏明确结论。因此,需要更多来自注册研究的结果。
2009年9月1日至2013年4月15日期间,共有17587例患者前瞻性纳入了Herniamed注册研究。其中,10887例(61.9%)接受了TAPP手术,6700例(38.1%)接受了TEP修补术。因变量为术中及术后并发症发生率、再次手术次数以及绝对和相对频率。未经调整分析的结果通过多变量分析进行验证。
多变量分析验证了未经调整分析的结果,表明手术技术在考虑其他因素的情况下,对术中并发症的发生[p = 0.1648;OR = 1.214(0.923;1.596)]和一般术后并发症的发生[p = 0.0738;OR = 1.315(0.974;1.775)]均无显著影响。TAPP术后手术并发症[OR = 2.323(1.882;2.866);p < 0.0001]更为常见。此外,疝缺损大小[p < 0.0001;I级与III级:OR = 0.439(0.313;0.615),II级与III级:OR = 0.712(0.582;0.872)]、阴囊疝[p < 0.0001;OR = 2.170(1.501;3.137)]和年龄[p = 0.0002;每10年OR = 1.135(1.062;1.213)]对术后并发症的发生有显著影响。较大的疝缺损和阴囊疝更容易出现并发症。然而,TEP和TAPP术后并发症发生率的差异并未导致再次手术率出现差异(TEP为0.82%,TAPP为0.90%;p = 0.6165)。
TEP和TAPP在术中及一般术后并发症发生率以及并发症再次手术率方面无显著差异。TAPP术后较高的并发症发生率可通过保守治疗处理,部分原因是缺损较大、阴囊疝较多以及患者年龄较大。