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Changes in the ratio of two separate toxin binding sites on the sodium channel protein during rat brain development.

作者信息

Baumgold J

出版信息

Brain Res. 1985 Jan;349(1-2):271-4. doi: 10.1016/0165-3806(85)90153-1.

DOI:10.1016/0165-3806(85)90153-1
PMID:2580602
Abstract

The development of two separate toxin binding sites from sodium channels of rat brain was studied. Whereas [3H]saxitoxin binding developed gradually, reaching adult levels by 4.5 weeks after birth, the binding of [125I]scorpion toxin increased rapidly for the first 10 days after birth, then declined. The stoichiometric ratio of [3H]saxitoxin binding site to [125I]scorpion toxin binding sites changed during development from 0.5 in 8 day old rats to 1.9 in adult rats, implying separate biological regulation for each of these sites.

摘要

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