Callaly Edward, Walder Ken, Morris Gerwyn, Maes Michael, Debnath Monojit, Berk Michael
School of Medicine, Deakin University, Waurn Ponds, Geelong, Australia.
Mini Rev Med Chem. 2015;15(5):355-65. doi: 10.2174/1389557515666150324122026.
Bipolar disorder is a common, chronic, and complex mental illness. Bipolar disorder is frequently comorbid with primary mitochondrial and metabolic disorders, and studies have implicated mitochondrial dysfunction in its pathophysiology. In the brains of people with bipolar disorder, high-energy phosphates are decreased, lactate is elevated and pH decreased, which together suggest a shift toward glycolysis for energy production. Furthermore, oxidative stress is increased, and calcium signalling dysregulated. Additionally there is downregulation of the expression of mitochondrial complexes, especially complex I. The therapeutic effects of some bipolar disorder drugs have recently been shown to be related to these mechanisms. In this review we will evaluate current research on the interactions between mitochondrial dysfunction and bipolar disorder pathology. We will then appraise the current literature describing the effects of bipolar disorder drugs on mitochondrial function, and discuss ramifications for future research.
双相情感障碍是一种常见、慢性且复杂的精神疾病。双相情感障碍常与原发性线粒体和代谢紊乱共病，并且研究表明线粒体功能障碍参与其病理生理学过程。在双相情感障碍患者的大脑中，高能磷酸盐减少，乳酸升高，pH值降低，这些共同表明能量产生向糖酵解方向转变。此外，氧化应激增加，钙信号传导失调。另外，线粒体复合物的表达下调，尤其是复合物I。最近已表明一些双相情感障碍药物的治疗效果与这些机制有关。在本综述中，我们将评估目前关于线粒体功能障碍与双相情感障碍病理学之间相互作用的研究。然后，我们将评价描述双相情感障碍药物对线粒体功能影响的当前文献，并讨论对未来研究的影响。
