根据莱施分型法，酗酒者中单胺氧化酶A启动子串联重复序列可变数目（MAOA-uVNTR）的情况。

Monoamine oxidase a promoter variable number of tandem repeats (MAOA-uVNTR) in alcoholics according to Lesch typology.

作者信息

Samochowiec Agnieszka, Chęć Magdalena, Kopaczewska Edyta, Samochowiec Jerzy, Lesch Otto, Grochans Elżbieta, Jasiewicz Andrzej, Bienkowski Przemyslaw, Łukasz Kołodziej, Grzywacz Anna

机构信息

Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Krakowska 69, 71-017 Szczecin, Poland.

University Center for Education, University of Szczecin, Szwoleżerów 18a, 71-062 Szczecin, Poland.

出版信息

Int J Environ Res Public Health. 2015 Mar 19;12(3):3317-26. doi: 10.3390/ijerph120303317.

DOI:10.3390/ijerph120303317

PMID:25809512

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4377966/

Abstract

BACKGROUND

The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch's typology.

METHODS

DNA was provided from alcohol dependent (AD) patients (n=370) and healthy control subjects (n=168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods.

RESULTS

We found no association between alcohol dependence and MAOA gene polymorphism.

CONCLUSIONS

Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.

摘要

背景

本研究的目的是在根据莱施分型法分类的酒精依赖患者同质亚组中，检测单胺氧化酶A基因可变数目串联重复序列（MAOA-uVNTR）基因多态性之间的关联。

方法

提供了来自均为波兰血统的酒精依赖（AD）患者（n = 370）和健康对照者（n = 168）的DNA。使用波兰语版酒精中毒遗传学半结构化评估（SSAGA）获取酗酒史。采用聚合酶链反应（PCR）方法对样本进行基因分型。

结果

我们发现酒精依赖与MAOA基因多态性之间无关联。

结论

莱施分型法是该疾病的临床结果，其表型描述过于复杂，无法进行简单的基因分析。

相似文献

Monoamine oxidase a promoter variable number of tandem repeats (MAOA-uVNTR) in alcoholics according to Lesch typology.

Int J Environ Res Public Health. 2015 Mar 19;12(3):3317-26. doi: 10.3390/ijerph120303317.

Case control study of ANKK1 Taq 1A polymorphism in patients with alcohol dependence classified according to Lesch's typology.

Postepy Hig Med Dosw (Online). 2016 May 4;70:420-4. doi: 10.5604/17322693.1201125.

Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan.

Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):108-14. doi: 10.1016/j.pnpbp.2006.08.010. Epub 2006 Sep 27.

MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder.

Alcohol Clin Exp Res. 2009 Jun;33(6):985-90. doi: 10.1111/j.1530-0277.2009.00919.x. Epub 2009 Mar 19.

MAOA-uVNTR polymorphism in a Brazilian sample: further support for the association with impulsive behaviors and alcohol dependence.

Am J Med Genet B Neuropsychiatr Genet. 2006 Apr 5;141B(3):305-8. doi: 10.1002/ajmg.b.30290.

Genetics of Lesch's typology of alcoholism.

Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):423-7. doi: 10.1016/j.pnpbp.2007.09.013. Epub 2007 Sep 22.

Associations Between MAOA-uVNTR Genotype, Maltreatment, MAOA Methylation, and Alcohol Consumption in Young Adult Males.

Alcohol Clin Exp Res. 2018 Mar;42(3):508-519. doi: 10.1111/acer.13578. Epub 2018 Jan 31.

A functional polymorphism in the MAOA gene promoter (MAOA-LPR) predicts central dopamine function and body mass index.

Mol Psychiatry. 2006 Sep;11(9):858-66. doi: 10.1038/sj.mp.4001856. Epub 2006 Jun 13.

MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependence.

Alcohol Clin Exp Res. 2010 Jul;34(7):1212-8. doi: 10.1111/j.1530-0277.2010.01198.x. Epub 2010 May 7.

VNTR polymorphism in the monoamine oxidase A promoter region and cerebrospinal fluid catecholamine concentrations in forensic autopsy cases.

Neurosci Lett. 2019 May 14;701:71-76. doi: 10.1016/j.neulet.2019.02.029. Epub 2019 Feb 19.

引用本文的文献

Serotonin transporter functional polymorphisms potentially increase risk of schizophrenia separately and as a haplotype.

Sci Rep. 2022 Jan 25;12(1):1336. doi: 10.1038/s41598-022-05206-x.

The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.

Prog Neurobiol. 2020 Nov;194:101875. doi: 10.1016/j.pneurobio.2020.101875. Epub 2020 Jun 20.

Correction: Samochowiec, A., et al. Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology. Int. J. Environ. Res. Public Health 2015, 12, 3317-3326.

Int J Environ Res Public Health. 2015 Jun 16;12(6):6892-3. doi: 10.3390/ijerph120606892.

本文引用的文献

Genetics of alcohol dependence: a review of clinical studies.

Neuropsychobiology. 2014;70(2):77-94. doi: 10.1159/000364826. Epub 2014 Oct 30.

Candidate genes for aggression and antisocial behavior: a meta-analysis of association studies of the 5HTTLPR and MAOA-uVNTR.

Behav Genet. 2014 Sep;44(5):427-44. doi: 10.1007/s10519-014-9661-y. Epub 2014 Jun 6.

Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence.

Eur Addict Res. 2013;19(1):55-9. doi: 10.1159/000341714. Epub 2012 Sep 18.

GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects.

Arch Med Sci. 2012 May 9;8(2):357-61. doi: 10.5114/aoms.2012.28565.

Family-based study of brain-derived neurotrophic factor (BDNF) gene polymorphism in alcohol dependence.

Pharmacol Rep. 2010 Sep-Oct;62(5):938-41. doi: 10.1016/s1734-1140(10)70354-6.

Harsh discipline, childhood sexual assault, and MAOA genotype: an investigation of main and interactive effects on diverse clinical externalizing outcomes.

Behav Genet. 2010 Sep;40(5):639-48. doi: 10.1007/s10519-010-9358-9. Epub 2010 Apr 4.

MAOA methylation is associated with nicotine and alcohol dependence in women.

Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):565-70. doi: 10.1002/ajmg.b.30778.

Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence.

Neurosci Lett. 2006 Dec 13;410(1):1-5. doi: 10.1016/j.neulet.2006.05.005. Epub 2006 Oct 31.

MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis.

Mol Psychiatry. 2006 Oct;11(10):903-13. doi: 10.1038/sj.mp.4001851. Epub 2006 Jun 27.

MAOA-uVNTR polymorphism in a Brazilian sample: further support for the association with impulsive behaviors and alcohol dependence.

Am J Med Genet B Neuropsychiatr Genet. 2006 Apr 5;141B(3):305-8. doi: 10.1002/ajmg.b.30290.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

根据莱施分型法，酗酒者中单胺氧化酶A启动子串联重复序列可变数目（MAOA-uVNTR）的情况。

Monoamine oxidase a promoter variable number of tandem repeats (MAOA-uVNTR) in alcoholics according to Lesch typology.

作者信息

Samochowiec Agnieszka, Chęć Magdalena, Kopaczewska Edyta, Samochowiec Jerzy, Lesch Otto, Grochans Elżbieta, Jasiewicz Andrzej, Bienkowski Przemyslaw, Łukasz Kołodziej, Grzywacz Anna

机构信息

Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Krakowska 69, 71-017 Szczecin, Poland.

University Center for Education, University of Szczecin, Szwoleżerów 18a, 71-062 Szczecin, Poland.

出版信息

Int J Environ Res Public Health. 2015 Mar 19;12(3):3317-26. doi: 10.3390/ijerph120303317.

DOI:10.3390/ijerph120303317

PMID:25809512

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4377966/

Abstract

BACKGROUND

The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch's typology.

METHODS

RESULTS

We found no association between alcohol dependence and MAOA gene polymorphism.

CONCLUSIONS

Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.

摘要

背景

本研究的目的是在根据莱施分型法分类的酒精依赖患者同质亚组中，检测单胺氧化酶A基因可变数目串联重复序列（MAOA-uVNTR）基因多态性之间的关联。

方法

结果

我们发现酒精依赖与MAOA基因多态性之间无关联。

结论

莱施分型法是该疾病的临床结果，其表型描述过于复杂，无法进行简单的基因分析。

根据莱施分型法，酗酒者中单胺氧化酶A启动子串联重复序列可变数目（MAOA-uVNTR）的情况。

Monoamine oxidase a promoter variable number of tandem repeats (MAOA-uVNTR) in alcoholics according to Lesch typology.

作者信息

机构信息

出版信息

BACKGROUND

METHODS

RESULTS

CONCLUSIONS

背景

方法

结果

结论

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

根据莱施分型法，酗酒者中单胺氧化酶A启动子串联重复序列可变数目（MAOA-uVNTR）的情况。

Monoamine oxidase a promoter variable number of tandem repeats (MAOA-uVNTR) in alcoholics according to Lesch typology.

作者信息

机构信息

出版信息

BACKGROUND

METHODS

RESULTS

CONCLUSIONS

背景

方法

结果

结论