GABA-A 受体基因在高加索人群的 Lesch 型遗传中不起作用。
GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects.
机构信息
Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
出版信息
Arch Med Sci. 2012 May 9;8(2):357-61. doi: 10.5114/aoms.2012.28565.
INTRODUCTION
Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system.
MATERIAL AND METHODS
We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch's typology and in 145 matched controls.
RESULTS
Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls.
CONCLUSIONS
Lesch's typology may not be related with the genotype of alcoholics - at least in terms of genes with an established role in the development of dependency.
介绍
莱希氏分类将酗酒者分为不同的治疗反应亚组。乙醇的作用在很大程度上是通过 GABA 能系统介导的。
材料与方法
我们评估了根据莱希氏分类法分为 133 名酗酒者和 145 名匹配对照者的 GABRG1 和 GABRA2 基因的连锁不平衡模式和单倍型频率。
结果
除了一些达到统计学显著性阈值的关系外，我们没有发现这些基因的单倍型分布在酗酒者和对照组之间有显著差异。
结论
莱希氏分类法与酗酒者的基因型可能没有关系——至少在那些对依赖性发展有明确作用的基因方面是如此。
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