Hagino Y, Nomura H, Nomura T, Maekawa H, Izuhara K, Tachibana M
Jpn J Pharmacol. 1985 Jan;37(1):133-6. doi: 10.1254/jjp.37.133.
The change in responsiveness to alpha-adrenergic stimulation and to calcium ions in amylase release from parotid glands of hypothyroid rats was compared with that in euthyroid rats. Calcium depletion and addition of verapamil or W-7 in the medium caused a decrease in methoxamine-induced amylase release in both eu- and hypothyroid rats. Moreover, addition of calcium ions to Ca2+-free medium markedly increased the methoxamine-induced amylase release in proportion to its concentration in hypothyroid rats. These results suggest that calcium ions play an important role in methoxamine-induced amylase release from parotid glands of hypothyroid rats as well as those of the euthyroid ones.