Hagino Y, Nomura H, Nomura T, Maekawa H, Izuhara K, Tachibana M
Jpn J Pharmacol. 1985 Jan;37(1):133-6. doi: 10.1254/jjp.37.133.
The change in responsiveness to alpha-adrenergic stimulation and to calcium ions in amylase release from parotid glands of hypothyroid rats was compared with that in euthyroid rats. Calcium depletion and addition of verapamil or W-7 in the medium caused a decrease in methoxamine-induced amylase release in both eu- and hypothyroid rats. Moreover, addition of calcium ions to Ca2+-free medium markedly increased the methoxamine-induced amylase release in proportion to its concentration in hypothyroid rats. These results suggest that calcium ions play an important role in methoxamine-induced amylase release from parotid glands of hypothyroid rats as well as those of the euthyroid ones.
将甲状腺功能减退大鼠腮腺淀粉酶释放中对α-肾上腺素能刺激和钙离子的反应性变化与甲状腺功能正常大鼠进行了比较。培养基中钙耗尽以及添加维拉帕米或W-7导致甲状腺功能正常和减退大鼠中甲氧明诱导的淀粉酶释放均减少。此外，向无钙培养基中添加钙离子可显著增加甲氧明诱导的淀粉酶释放，且在甲状腺功能减退大鼠中与钙离子浓度成比例增加。这些结果表明，钙离子在甲氧明诱导的甲状腺功能减退大鼠和甲状腺功能正常大鼠腮腺淀粉酶释放中均起重要作用。
