Lauva I K, Tomanek R J
J Cardiovasc Pharmacol. 1985 Mar-Apr;7(2):232-7. doi: 10.1097/00005344-198503000-00004.
We evaluated the role of chronic cardioselective beta-adrenoceptor blockade in left ventricular (LV) function in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Commencing at 4 weeks of age, the animals were injected twice daily (20 mg/kg) with atenolol and were studied at either 10 or 16 weeks of age, to compare the stages of developing and established hypertension in SHR. Both blood pressure and LV mass were attenuated in the treated SHR. Ventricular function-evaluated by increasing preload (infusion of Tyrode solution) and recording indices of peak cardiac output, i.e., cardiac index (CI), stroke index (SI), and acceleration of flow-was similar in SHR and WKY at both 10 and 16 weeks of age. At 10 weeks, peak CI and SI were not significantly different in treated and non-treated SHR. By 16 weeks, however, atenolol treatment was associated with a significant decrease in peak CI (20%) attributable mainly to a lower SI. LV end-diastolic and systolic pressures were not affected by chronic treatment with the beta-adrenoceptor antagonist. It is concluded that, when prolonged atenolol treatment is initiated during early postnatal life, peak LV function in SHR is compromised.
我们评估了慢性心脏选择性β-肾上腺素能受体阻滞剂对自发性高血压大鼠（SHR）和正常血压的Wistar-Kyoto大鼠（WKY）左心室（LV）功能的作用。从4周龄开始，每天给动物注射两次阿替洛尔（20 mg/kg），并在10周或16周龄时进行研究，以比较SHR中高血压发展和确立阶段的情况。在接受治疗的SHR中，血压和左心室质量均有所降低。通过增加前负荷（输注台氏液）并记录心输出量峰值指标，即心脏指数（CI）、每搏输出指数（SI）和血流加速度来评估心室功能，结果显示10周龄和16周龄时SHR和WKY的心室功能相似。在10周时，接受治疗和未接受治疗的SHR的峰值CI和SI没有显著差异。然而，到16周时，阿替洛尔治疗导致峰值CI显著降低（20%），主要归因于较低的SI。β-肾上腺素能受体拮抗剂的长期治疗未影响左心室舒张末期和收缩期压力。得出的结论是，在出生后早期开始长期阿替洛尔治疗时，SHR的左心室功能峰值会受到损害。
