• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2013 - 14年流感季节美国佛罗里达州甲型H1N1流感疾病的严重程度及D225G变异株的出现

Severity of influenza A(H1N1) illness and emergence of D225G variant, 2013-14 influenza season, Florida, USA.

作者信息

Iovine Nicole M, Morris J Glenn, Fredenburg Kristianna, Rand Kenneth, Alnuaimat Hassan, Lipori Gloria, Brew Joseph, Lednicky John A

出版信息

Emerg Infect Dis. 2015 Apr;21(4):664-7. doi: 10.3201/eid2104.141375.

DOI:10.3201/eid2104.141375
PMID:25811540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4378462/
Abstract

Despite a regional decline in influenza A(H1N1)pdm09 virus infections during 2013-14, cases at a Florida hospital were more severe than those during 2009-10. Examined strains had a hemagglutinin polymorphism associated with enhanced binding to lower respiratory tract receptors. Genetic changes in this virus must be monitored to predict the effect of future pandemic viruses.

摘要

尽管2013 - 14年甲型H1N1流感大流行病毒（A(H1N1)pdm09）感染在该地区有所下降，但佛罗里达州一家医院的病例比2009 - 10年更为严重。所检测的毒株具有一种与增强对下呼吸道受体结合相关的血凝素多态性。必须监测该病毒的基因变化，以预测未来大流行病毒的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b070/4378462/10ddcbf19efb/14-1375-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b070/4378462/a39fa9665f00/14-1375-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b070/4378462/10ddcbf19efb/14-1375-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b070/4378462/a39fa9665f00/14-1375-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b070/4378462/10ddcbf19efb/14-1375-F2.jpg

相似文献

1
Severity of influenza A(H1N1) illness and emergence of D225G variant, 2013-14 influenza season, Florida, USA.2013 - 14年流感季节美国佛罗里达州甲型H1N1流感疾病的严重程度及D225G变异株的出现
Emerg Infect Dis. 2015 Apr;21(4):664-7. doi: 10.3201/eid2104.141375.
2
D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice.D225G 突变使大流行性流感 H1N1（2009）病毒血凝素的毒力增强。
Exp Biol Med (Maywood). 2010 Aug;235(8):981-8. doi: 10.1258/ebm.2010.010071.
3
Molecular genetic analysis of the Influenza A(H1N1)pdm09 virus from lethal and recovered cases in Russia from 2009 to 2014: Deletions in the nucleoprotein.2009年至2014年俄罗斯致死和康复病例中甲型H1N1pdm09流感病毒的分子遗传学分析：核蛋白中的缺失
Infect Genet Evol. 2015 Aug;34:160-72. doi: 10.1016/j.meegid.2015.07.019. Epub 2015 Jul 17.
4
Molecular characterization and phylogenetic analysis of the hemagglutinin 1 protein of human influenza A virus subtype H1N1 circulating in Kenya during 2007-2008.2007-2008 年肯尼亚流行的 H1N1 型人甲型流感病毒血凝素 1 蛋白的分子特征和系统进化分析。
J Infect Dis. 2012 Dec 15;206 Suppl 1:S46-52. doi: 10.1093/infdis/jis586.
5
Molecular epidemiology and evolution of A(H1N1)pdm09 and H3N2 virus during winter 2012-2013 in Beijing, China.2012 - 2013年冬季中国北京甲型H1N1流感大流行病毒和H3N2病毒的分子流行病学及进化情况
Infect Genet Evol. 2014 Aug;26:228-40. doi: 10.1016/j.meegid.2014.05.034. Epub 2014 Jun 7.
6
Intensive care unit surveillance of influenza infection in France: the 2009/10 pandemic and the three subsequent seasons.法国重症监护病房流感感染监测：2009/10 年大流行及随后的三个季节。
Euro Surveill. 2015;20(46). doi: 10.2807/1560-7917.ES.2015.20.46.30066.
7
Emergent 2009 influenza A(H1N1) viruses containing HA D222N mutation associated with severe clinical outcomes in the Americas.在美洲，与严重临床结果相关的含 HA D222N 突变的 2009 年甲型 H1N1 流感病毒呈紧急状态。
J Clin Virol. 2012 Jan;53(1):12-5. doi: 10.1016/j.jcv.2011.09.004. Epub 2011 Oct 28.
8
Quasispecies of the D225G substitution in the hemagglutinin of pandemic influenza A(H1N1) 2009 virus from patients with severe disease in Hong Kong, China.中国香港严重疾病患者中流行的 A(H1N1)2009 病毒血凝素 D225G 取代的准种。
J Infect Dis. 2010 May 15;201(10):1517-21. doi: 10.1086/652661.
9
Population Responses during the Pandemic Phase of the Influenza A(H1N1)pdm09 Epidemic, Hong Kong, China.中国香港甲型H1N1流感大流行期间的人群反应
Emerg Infect Dis. 2017 May;23(5):813-815. doi: 10.3201/eid2305.160768.
10
Evolutionary dynamics of 2009 pandemic influenza A virus subtype H1N1 in South Africa during 2009-2010.2009-2010 年南非 2009 年大流行性流感 A 病毒 H1N1 亚型的进化动态。
J Infect Dis. 2012 Dec 15;206 Suppl 1:S166-72. doi: 10.1093/infdis/jis539.

引用本文的文献

1
Identification of H3N2 NA and PB1-F2 genetic variants and their association with disease symptoms during the 2014-15 influenza season.2014 - 2015年流感季节期间H3N2神经氨酸酶（NA）和PB1 - F2基因变异体的鉴定及其与疾病症状的关联。
Virus Evol. 2021 Jun 4;7(1):veab047. doi: 10.1093/ve/veab047. eCollection 2021 Jan.
2
Earliest detection to date of SARS-CoV-2 in Florida: Identification together with influenza virus on the main entry door of a university building, February 2020.迄今为止在美国佛罗里达州对 SARS-CoV-2 的最早检测：2020 年 2 月在一所大学建筑物的主要入口门上同时发现了流感病毒和 SARS-CoV-2。
PLoS One. 2021 Jan 13;16(1):e0245352. doi: 10.1371/journal.pone.0245352. eCollection 2021.
3

本文引用的文献

1
Detection and Isolation of Airborne Influenza A H3N2 Virus Using a Sioutas Personal Cascade Impactor Sampler.使用Sioutas个人级联撞击采样器检测和分离空气传播的甲型H3N2流感病毒
Influenza Res Treat. 2013;2013:656825. doi: 10.1155/2013/656825. Epub 2013 Oct 10.
2
Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution.通过 D225G 取代，揭示了 1918 年和 2009 年大流行流感 A 病毒血凝素受体结合特异性开关的分子基础。
J Virol. 2013 May;87(10):5949-58. doi: 10.1128/JVI.00545-13. Epub 2013 Mar 20.
3
Clinical and molecular characteristics of the 2009 pandemic influenza H1N1 infection with severe or fatal disease from 2009 to 2011 in Shenzhen, China.
Collection of Viable Aerosolized Influenza Virus and Other Respiratory Viruses in a Student Health Care Center through Water-Based Condensation Growth.
通过水基冷凝生长在学生健康护理中心收集活的雾化流感病毒和其他呼吸道病毒。
mSphere. 2017 Oct 11;2(5). doi: 10.1128/mSphere.00251-17. eCollection 2017 Sep-Oct.
4
Drifted Influenza A and B Viruses Collected by a Water-Based Condensation Growth Air Sampler in a Student Health Care Center during an Influenza Outbreak.在一次流感暴发期间，通过水基冷凝生长空气采样器在学生保健中心收集的甲型和乙型流感病毒漂移株
Genome Announc. 2017 Apr 13;5(15):e00178-17. doi: 10.1128/genomeA.00178-17.
5
Hemagglutinin Gene Clade 3C.2a Influenza A(H3N2) Viruses, Alachua County, Florida, USA, 2014-15.2014 - 2015年美国佛罗里达州阿拉楚阿县血凝素基因3C.2a亚分支甲型H3N2流感病毒
Emerg Infect Dis. 2016 Jan;22(1):121-3. doi: 10.3201/2201.151019.
6
Comparative Analysis of Whole-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Hospitalized and Nonhospitalized Patients Identifies Missense Mutations That Might Be Associated with Patient Hospital Admissions in Finland during 2009 to 2014.对2009年至2014年期间从芬兰住院和非住院患者中分离出的甲型（H1N1）pdm09流感病毒全基因组序列进行比较分析，确定了可能与患者住院相关的错义突变。
Genome Announc. 2015 Jul 30;3(4):e00676-15. doi: 10.1128/genomeA.00676-15.
2009-2011 年中国深圳严重或致命性 2009 年大流行流感 H1N1 感染的临床和分子特征。
J Med Virol. 2013 Mar;85(3):405-12. doi: 10.1002/jmv.23295. Epub 2012 Dec 21.
4
Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.英国大流行性流感 A（H1N1）2009 的进化途径。
PLoS One. 2011;6(8):e23779. doi: 10.1371/journal.pone.0023779. Epub 2011 Aug 24.
5
Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection.2009年甲型H1N1流感大流行病毒感染的临床特征
N Engl J Med. 2010 May 6;362(18):1708-19. doi: 10.1056/NEJMra1000449.
6
Quasispecies of the D225G substitution in the hemagglutinin of pandemic influenza A(H1N1) 2009 virus from patients with severe disease in Hong Kong, China.中国香港严重疾病患者中流行的 A(H1N1)2009 病毒血凝素 D225G 取代的准种。
J Infect Dis. 2010 May 15;201(10):1517-21. doi: 10.1086/652661.
7
Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China.中国 2009 年甲型 H1N1 流感大流行病毒感染初始病例的临床特征。
N Engl J Med. 2009 Dec 24;361(26):2507-17. doi: 10.1056/NEJMoa0906612. Epub 2009 Dec 9.
8
Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray.通过碳水化合物微阵列测定2009年甲型H1N1大流行性流感病毒的受体结合特异性
Nat Biotechnol. 2009 Sep;27(9):797-9. doi: 10.1038/nbt0909-797.
9
The pathology of influenza virus infections.流感病毒感染的病理学
Annu Rev Pathol. 2008;3:499-522. doi: 10.1146/annurev.pathmechdis.3.121806.154316.
10
Avian flu: influenza virus receptors in the human airway.禽流感：人类气道中的流感病毒受体
Nature. 2006 Mar 23;440(7083):435-6. doi: 10.1038/440435a.