Michelson A M, Lacour F, Lacour J
Proc Soc Exp Biol Med. 1985 May;179(1):1-8. doi: 10.3181/00379727-179-42055.
The biological properties of polyadenylic . polyuridylic acid (Poly(A) . Poly(U] are discussed and the application to the treatment of cancer in various animal models is described. Pharmacokinetic properties are presented and the results of clinical application to humans with specific reference to adjuvant treatment of breast cancer are examined in some detail. Given these results and the total lack of toxicity or of secondary effects of Poly(A) . Poly(U) it appears that further development and application of this polynucleotide complex are certainly justified in terms of clinical use in cancer and perhaps in viral pathologies.
本文讨论了聚腺苷酸-聚尿苷酸（Poly(A)·Poly(U)）的生物学特性，并描述了其在各种动物模型中治疗癌症的应用。介绍了其药代动力学特性，并详细研究了其在人类临床应用的结果，特别提及了对乳腺癌辅助治疗的情况。鉴于这些结果以及Poly(A)·Poly(U)完全没有毒性或副作用，看来这种多核苷酸复合物在癌症临床应用以及可能在病毒病理学方面的进一步开发和应用是完全合理的。
