下丘中异常的γ-氨基丁酸能系统为遗传性癫痫易感大鼠的听源性癫痫发作提供了基础。
An abnormal GABAergic system in the inferior colliculus provides a basis for audiogenic seizures in genetically epilepsy-prone rats.
作者信息
Ribak Charles E
机构信息
Department of Anatomy and Neurobiology, School of Medicine, University of California at Irvine, Irvine, CA 92697-1275, USA.
出版信息
Epilepsy Behav. 2017 Jun;71(Pt B):160-164. doi: 10.1016/j.yebeh.2015.02.024. Epub 2015 Mar 23.
Abstract
In this review of neuroanatomical studies of the genetically epilepsy-prone rat (GEPR), three main topics will be covered. First, the number of GABAergic neurons and total neurons in the inferior colliculus of GEPRs will be compared to those of the nonepileptic Sprague-Dawley rat. Next, the number of small neurons in the inferior colliculus will be described in both developmental and genetic analyses of GEPRs and their backcrosses. Last, results from two types of studies on the propagation pathways for audiogenic seizures in GEPRs will be shown. Together, these studies demonstrate a unique GABAergic, small neuron defect in the inferior colliculus of GEPRs that may play a vital role in the initiation and spread of seizure activity during audiogenic seizures. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic".
摘要
在这篇对遗传性癫痫易感大鼠（GEPR）的神经解剖学研究综述中，将涵盖三个主要主题。首先，将比较GEPR下丘中的γ-氨基丁酸能神经元数量和总神经元数量与非癫痫性斯普拉格-道利大鼠的相应数量。其次，将在GEPR及其回交后代的发育和遗传分析中描述下丘中小神经元的数量。最后，将展示关于GEPR听源性癫痫发作传播途径的两种研究类型的结果。这些研究共同证明了GEPR下丘中独特的γ-氨基丁酸能小神经元缺陷，这可能在听源性癫痫发作期间癫痫活动的起始和传播中起至关重要的作用。本文是名为“遗传性和反射性癫痫、听源性癫痫发作及品系：从实验模型到临床”的特刊的一部分。
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