Cui Jianguo, Lin Qifu, Gan Chunfang, Zhan Junyan, Su Wei, Zhao Dandan, Qi Binbin, Huang Yanmin
College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
Steroids. 2015 Jun;98:138-42. doi: 10.1016/j.steroids.2015.03.012. Epub 2015 Mar 23.
Using 3β-hydroxy-5-androsten-17-one as a starting material, a series of novel nitrogen-containing B-nor-D-homosteroids were designed and synthesized by the oximation, Beckman rearrangement, ozonation, cyclization and condensation reaction. The structures of all new compounds were determined by analysis of their NMR, MS and IR spectra. The antiproliferative activity of compounds was evaluated against HT-29 (colonic carcinoma), HeLa (human cervical carcinoma) and Bel 7404 (human liver carcinoma) cells.
