Alba Toll, Anna Mané, Institut de Neuropsiquitria i Addiccions, Parc de Salut Mar, 08003 Barcelona, Spain.
World J Psychiatry. 2015 Mar 22;5(1):154-9. doi: 10.5498/wjp.v5.i1.154.
To systematically review studies measuring peripheric brain-derived neurotrophic factor (BDNF) levels on first-episode psychosis patients and variables related to them.
A systematic search was made of articles published in the Medline database from 2002 up to June 2014. Included are original studies that report enzyme-linked immunosorbent assay measurement of BDNF levels in serum or plasma in patients with a diagnosis of first episode psychosis (FEP) and age- and gender- matched healthy controls.
Of the initially identified 147 articles, only 18 satisfied the inclusion criteria. Of this, 15 found a significant reduction in patients with FEP compared with age- and gender - matched controls.
Peripheral BDNF levels are generally reduced in FEP patients. There are some factors that may influence BDNF levels that need to be further studied. Furthermore, a future meta-analysis in this topic is needed.
系统回顾外周脑源性神经营养因子（BDNF）水平测量首发精神分裂症患者及相关变量的研究。
对 2002 年至 2014 年 6 月间 Medline 数据库发表的文章进行系统检索。纳入的原始研究报告了酶联免疫吸附测定法在血清或血浆中检测首发精神分裂症（FEP）患者和年龄及性别匹配的健康对照者外周 BDNF 水平的结果。
最初确定的 147 篇文章中，仅有 18 篇符合纳入标准。其中，15 项研究发现 FEP 患者外周 BDNF 水平显著低于年龄和性别匹配的对照组。
外周 BDNF 水平在首发精神分裂症患者中普遍降低。有一些可能影响 BDNF 水平的因素需要进一步研究。此外，该主题需要进行未来的荟萃分析。
