Murphy Brendan P, Pang Terence Y, Hannan Anthony J, Proffitt Tina-Marie, McConchie Mirabel, Kerr Melissa, Markulev Connie, O'Donnell Colin, McGorry Patrick D, Berger Gregor E
Early in Life Mental Health Service, Southern Health, Melbourne, VIC 3175, Australia ; School of Psychology and Psychiatry, Monash University, Melbourne, VIC 3800, Australia.
Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne, Melbourne, VIC 3052, Australia.
Schizophr Res Treatment. 2014;2014:719395. doi: 10.1155/2014/719395. Epub 2014 Feb 5.
Objective. It has been suggested that atypical antipsychotics confer their effects via brain-derived neurotrophic factor (BDNF). We investigated the effect of quetiapine on serum levels of BDNF and vascular endothelial growth factor (VEGF) in drug-naive first-episode psychosis subjects. Methods. Fifteen patients drawn from a larger study received quetiapine treatment for twelve weeks. Baseline levels of serum BDNF and VEGF were compared to age- and sex-matched healthy controls and to levels following treatment. Linear regression analyses were performed to determine the relationship of BDNF and VEGF levels with outcome measures at baseline and week 12. Results. The mean serum BDNF level was significantly higher at week 12 compared to baseline and correlated with reductions in Brief Psychiatric Rating Scale (BPRS) and general psychopathology scores. Changes in serum VEGF levels also correlated significantly with a reduction in BPRS scores, a significant improvement in PANNS positive symptoms scores, and displayed a positive relationship with changes in BDNF levels. Conclusions. Our findings suggest that BDNF and VEGF are potential biomarkers for gauging improvement of psychotic symptoms. This suggests a novel neurotrophic-based mechanism of the drug effects of quetiapine on psychosis. This is the first report of VEGF perturbation in psychosis.
目的。有观点认为非典型抗精神病药物通过脑源性神经营养因子（BDNF）发挥作用。我们研究了喹硫平对初发未用药精神病患者血清BDNF和血管内皮生长因子（VEGF）水平的影响。方法。从一项更大规模研究中选取15名患者接受喹硫平治疗12周。将血清BDNF和VEGF的基线水平与年龄和性别匹配的健康对照进行比较，并与治疗后的水平进行比较。进行线性回归分析以确定基线和第12周时BDNF和VEGF水平与疗效指标之间的关系。结果。与基线相比，第12周时血清BDNF平均水平显著升高，且与简明精神病评定量表（BPRS）及总体精神病理学评分的降低相关。血清VEGF水平的变化也与BPRS评分的降低、阳性和阴性症状评定量表（PANNS）阳性症状评分的显著改善显著相关，并且与BDNF水平的变化呈正相关。结论。我们的研究结果表明，BDNF和VEGF是衡量精神病症状改善的潜在生物标志物。这提示了喹硫平治疗精神病药物效应的一种基于神经营养的新机制。这是关于精神病中VEGF紊乱的首次报道。
