Xu Yan-mei, Liao Xing-yun, Chen Xie-wan, Li De-zhi, Sun Jian-guo, Liao Rong-xia
Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, Shapingba District, Chongqing 400037, China.
Medical English Department, College of Basic Medicine, Third Military Medical University, Shapingba District, Chongqing 400038, China.
Biomed Res Int. 2015;2015:851841. doi: 10.1155/2015/851841. Epub 2015 Mar 1.
Radiotherapy (RT) is a key therapeutic strategy for lung cancer, the most common cause of cancer-related deaths worldwide, but radioresistance often occurs and leads to failure of RT. It is therefore important to clarify the mechanism underlying radioresistance in lung cancer. Cancer stem cells (CSCs) are considered the fundamental reason for radioresistance. MicroRNAs (miRNAs) have been regarded as important regulatory molecules of CSCs, carcinogenesis, and treatment response of cancers. It is crucial to clarify how regulation of miRNAs affects repair of DNA damage, redistribution, repopulation, reoxygenation, and radiosensitivity (5R) of lung cancer stem cells (LCSCs). A thorough understanding of the regulation of miRNAs affecting 5R of LCSCs has potential impact on identifying novel targets and thus may improve the efficacy of lung cancer radiotherapy.
放射治疗（RT）是肺癌的关键治疗策略，肺癌是全球癌症相关死亡的最常见原因，但放疗抵抗经常发生并导致放疗失败。因此，阐明肺癌放疗抵抗的潜在机制很重要。癌症干细胞（CSCs）被认为是放疗抵抗的根本原因。微小RNA（miRNAs）被视为CSCs、癌症发生和癌症治疗反应的重要调节分子。阐明miRNAs的调控如何影响肺癌干细胞（LCSCs）的DNA损伤修复、再分布、再增殖、再氧合和放射敏感性（5R）至关重要。深入了解影响LCSCs 5R的miRNAs调控，可能对识别新靶点有潜在影响，从而可能提高肺癌放疗的疗效。
