Verbrugghe Mathieu, Duprez Veerle, Beeckman Dimitri, Grypdonck Mieke, Quaghebeur Marijke, Verschueren Caroline, Verhaeghe Sofie, Van Hecke Ann
Author Affiliations: University Centre for Nursing and Midwifery, Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent (Mr Verbrugghe, Ms Duprez, and Drs Beeckman, Grypdonck, Verhaeghe, and Van Hecke); Department of Hematology, University Hospital Ghent, Ghent (Marijke Quaghebeur); Department of Head and Neck Cancer, University Hospital Antwerp, Antwerp, Belgium (Dr Verschueren).
Cancer Nurs. 2016 Mar-Apr;39(2):153-62. doi: 10.1097/NCC.0000000000000250.
Nonadherence in cancer patients taking oral anticancer drugs is common. Reasons for nonadherence are still not really understood as influencing factors are often complex, dynamic, and interrelated.
A qualitative study was conducted to gain insight into (non-)adherence behavior in patients taking oral tyrosine kinase inhibitors by exploring (1) processes and factors influencing (non-)adherence and (2) their interrelatedness.
Semistructured interviews were held with 30 patients of different ages and with different types of cancer. A grounded theory approach was used.
Three foci were found when dealing with oral tyrosine kinase inhibitors: (1) a focus on survival, (2) a focus on quality of life, and (3) a balance between survival and quality of life. The process of adherence was determined by a set of complex and interrelated influencing factors: treatment-related side effects, hope, anxiety, trust, and feedback mechanisms.
This qualitative study gives insight into processes and factors influencing (non-)adherence behavior in patients taking oral tyrosine kinase inhibitors. The results of this study can help healthcare professionals understand why patients taking oral tyrosine kinase inhibitors do not always adhere to their therapy.
Conditions should be created by which patients get maximum opportunity to establish a balance between survival and quality of life. An open climate and a trust-based relationship should be established in which patients feel comfortable to openly discuss their therapy and the difficulties they experience.
服用口服抗癌药物的癌症患者不依从治疗的情况很常见。由于影响因素往往复杂、动态且相互关联，不依从的原因仍未得到真正理解。
进行一项定性研究，通过探索（1）影响（不）依从的过程和因素以及（2）它们的相互关联性，深入了解服用口服酪氨酸激酶抑制剂患者的（不）依从行为。
对30名不同年龄、患有不同类型癌症的患者进行了半结构化访谈。采用扎根理论方法。
在处理口服酪氨酸激酶抑制剂时发现了三个重点：（1）关注生存，（2）关注生活质量，（3）生存与生活质量之间的平衡。依从过程由一系列复杂且相互关联的影响因素决定：治疗相关副作用、希望、焦虑、信任和反馈机制。
这项定性研究深入了解了影响服用口服酪氨酸激酶抑制剂患者（不）依从行为的过程和因素。本研究结果可帮助医护人员理解为何服用口服酪氨酸激酶抑制剂的患者并非总是坚持治疗。
应创造条件，让患者有最大机会在生存和生活质量之间建立平衡。应建立开放的氛围和基于信任的关系，让患者能够自在地公开讨论他们的治疗及所经历的困难。
