Kanno Atsushi, Masamune Atsushi, Okazaki Kazuichi, Kamisawa Terumi, Kawa Shigeyuki, Nishimori Isao, Tsuji Ichiro, Shimosegawa Tooru
From the *Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai; †Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Osaka; ‡Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo; §Center of Health, Safety, and Environmental Management, Shinshu University, Matsumoto; ∥Nishimori Clinic, Kochi; and ¶Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Pancreas. 2015 May;44(4):535-9. doi: 10.1097/MPA.0000000000000325.
To clarify the clinicoepidemiological features of autoimmune pancreatitis (AIP) in Japan, a nationwide epidemiological survey was conducted.
Patients with AIP who had visited selected hospitals in 2011 were surveyed. Autoimmune pancreatitis was diagnosed according to the revised clinical diagnostic criteria for AIP (Japan Pancreas Society 2011). The study consisted of 2 stage surveys; the number of patients with AIP was estimated by the first questionnaire, and their clinical features were assessed by the second questionnaire.
The estimated total number of AIP patients in 2011 was 5745 (95% confidence interval, 5325-6164), with an overall prevalence rate of 4.6 per 100,000 population. The number of patients who were newly diagnosed as AIP was estimated to be 1808 (95% confidence interval, 1597-2018), with an annual incidence rate of 1.4 per 100,000 population. The sex ratio (male to female) was 3.2, and the mean age was 66.3 (11.5). Among the 936 patients whose detailed clinical information was obtained, 86.4% of the patients presented high serum immunoglobulin G4 levels (≥135 mg/dL), and 82.3% received steroid therapy.
The data represent the current clinical features of AIP in Japan.
为阐明日本自身免疫性胰腺炎（AIP）的临床流行病学特征，开展了一项全国性的流行病学调查。
对2011年就诊于选定医院的AIP患者进行调查。根据修订后的AIP临床诊断标准（日本胰腺学会，2011年）诊断自身免疫性胰腺炎。该研究包括两阶段调查；通过第一份问卷估计AIP患者数量，通过第二份问卷评估其临床特征。
2011年AIP患者的估计总数为5745例（95%置信区间，5325 - 6164），总体患病率为每10万人口4.6例。新诊断为AIP的患者数量估计为1808例（95%置信区间，1597 - 2018），年发病率为每10万人口1.4例。男女比例为3.2，平均年龄为66.3岁（11.5）。在获得详细临床信息的936例患者中，86.4%的患者血清免疫球蛋白G4水平升高（≥135mg/dL），82.3%的患者接受了类固醇治疗。
这些数据代表了日本AIP的当前临床特征。
