• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Blocking the adhesion cascade at the premetastatic niche for prevention of breast cancer metastasis.在乳腺癌转移前生态位阻断黏附级联反应以预防转移。
Mol Ther. 2015 Jun;23(6):1044-1054. doi: 10.1038/mt.2015.45. Epub 2015 Mar 27.
2
The effect of soluble E-selectin on tumor progression and metastasis.可溶性E选择素对肿瘤进展和转移的影响。
BMC Cancer. 2016 May 24;16:331. doi: 10.1186/s12885-016-2366-2.
3
Prognostic impact of transcription factor Fra-1 in ER-positive breast cancer: contribution to a metastatic phenotype through modulation of tumor cell adhesive properties.转录因子Fra-1在雌激素受体阳性乳腺癌中的预后影响：通过调节肿瘤细胞黏附特性促成转移表型。
J Cancer Res Clin Oncol. 2015 Oct;141(10):1715-26. doi: 10.1007/s00432-015-1925-2. Epub 2015 Feb 10.
4
CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions.乳腺癌细胞表达的CD44变异体同工型在流动条件下是功能性E-选择素配体。
Am J Physiol Cell Physiol. 2015 Jan 1;308(1):C68-78. doi: 10.1152/ajpcell.00094.2014. Epub 2014 Oct 22.
5
E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases.靶向E-选择素的聚乙二醇化硫代适配体可预防乳腺癌转移。
Mol Ther Nucleic Acids. 2016 Dec 13;5(12):e399. doi: 10.1038/mtna.2016.103.
6
SDA, a DNA aptamer inhibiting E- and P-selectin mediated adhesion of cancer and leukemia cells, the first and pivotal step in transendothelial migration during metastasis formation.SDA是一种DNA适配体，可抑制癌症和白血病细胞中E-选择素和P-选择素介导的黏附，这是转移形成过程中跨内皮迁移的首要关键步骤。
PLoS One. 2014 Apr 3;9(4):e93173. doi: 10.1371/journal.pone.0093173. eCollection 2014.
7
High-density lipoprotein of patients with breast cancer complicated with type 2 diabetes mellitus promotes cancer cells adhesion to vascular endothelium via ICAM-1 and VCAM-1 upregulation.乳腺癌合并2型糖尿病患者的高密度脂蛋白通过上调细胞间黏附分子-1（ICAM-1）和血管细胞黏附分子-1（VCAM-1）促进癌细胞与血管内皮的黏附。
Breast Cancer Res Treat. 2016 Feb;155(3):441-55. doi: 10.1007/s10549-016-3696-0. Epub 2016 Feb 12.
8
Identification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targeting.鉴定针对 E-选择素的硫代适配体配体：针对炎症血管靶向的潜在应用。
PLoS One. 2010 Sep 30;5(9):e13050. doi: 10.1371/journal.pone.0013050.
9
Bone marrow endothelium-targeted therapeutics for metastatic breast cancer.用于转移性乳腺癌的骨髓内皮靶向治疗药物
J Control Release. 2014 Aug 10;187:22-9. doi: 10.1016/j.jconrel.2014.04.057. Epub 2014 May 10.
10
Cimetidine inhibits the adhesion of gastric cancer cells expressing high levels of sialyl Lewis x in human vascular endothelial cells by blocking E-selectin expression.西咪替丁通过阻断 E-选择素的表达抑制高表达唾液酸化路易斯 x 的胃癌细胞与人血管内皮细胞的黏附。
Int J Mol Med. 2011 Apr;27(4):537-44. doi: 10.3892/ijmm.2011.618. Epub 2011 Feb 14.

引用本文的文献

1
Breaking the premetastatic niche barrier: the role of endothelial cells and therapeutic strategies.打破转移前生态位屏障：内皮细胞的作用及治疗策略
Theranostics. 2025 May 25;15(13):6454-6475. doi: 10.7150/thno.113665. eCollection 2025.
2
Lung-specific metastasis: the coevolution of tumor cells and lung microenvironment.肺特异性转移：肿瘤细胞与肺微环境的共同进化
Mol Cancer. 2025 Apr 16;24(1):118. doi: 10.1186/s12943-025-02318-6.
3
Premetastatic niche mechanics and organotropism in breast cancer.乳腺癌中的前转移生态位机制与器官趋向性
NPJ Biol Phys Mech. 2025;2(1):11. doi: 10.1038/s44341-025-00015-5. Epub 2025 Apr 3.
4
The origin of brain malignancies at the blood-brain barrier.血脑屏障处脑恶性肿瘤的起源。
Cell Mol Life Sci. 2023 Sep 9;80(10):282. doi: 10.1007/s00018-023-04934-1.
5
The Brain Pre-Metastatic Niche: Biological and Technical Advancements.脑转移前生态位：生物学与技术进展。
Int J Mol Sci. 2023 Jun 13;24(12):10055. doi: 10.3390/ijms241210055.
6
Insights into the Molecular Mechanisms Mediating Extravasation in Brain Metastasis of Breast Cancer, Melanoma, and Lung Cancer.乳腺癌、黑色素瘤和肺癌脑转移中介导外渗的分子机制洞察
Cancers (Basel). 2023 Apr 12;15(8):2258. doi: 10.3390/cancers15082258.
7
Adhesion to the Brain Endothelium Selects Breast Cancer Cells with Brain Metastasis Potential.黏附于脑内皮细胞选择具有脑转移潜能的乳腺癌细胞。
Int J Mol Sci. 2023 Apr 11;24(8):7087. doi: 10.3390/ijms24087087.
8
Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?循环肿瘤细胞：离子转运是否有助于其在血管内的存活、黏附、外渗及转移器官趋向性？
Rev Physiol Biochem Pharmacol. 2022;182:139-175. doi: 10.1007/112_2021_68.
9
Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways.转移前生态位的特征：分子和细胞通路全景
Mol Biomed. 2021 Jan 30;2(1):3. doi: 10.1186/s43556-020-00022-z.
10
Lung-Derived Selectins Enhance Metastatic Behavior of Triple Negative Breast Cancer Cells.肺源性选择素增强三阴性乳腺癌细胞的转移行为。
Biomedicines. 2021 Oct 30;9(11):1580. doi: 10.3390/biomedicines9111580.

本文引用的文献

1
CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions.乳腺癌细胞表达的CD44变异体同工型在流动条件下是功能性E-选择素配体。
Am J Physiol Cell Physiol. 2015 Jan 1;308(1):C68-78. doi: 10.1152/ajpcell.00094.2014. Epub 2014 Oct 22.
2
Regulation of alternative splicing of CD44 in cancer.癌症中CD44可变剪接的调控
Cell Signal. 2014 Oct;26(10):2234-9. doi: 10.1016/j.cellsig.2014.07.011. Epub 2014 Jul 13.
3
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay.从乳腺癌患者的血液循环肿瘤细胞中鉴定出一种能够在异种移植模型中引发转移的细胞群体。
Nat Biotechnol. 2013 Jun;31(6):539-44. doi: 10.1038/nbt.2576. Epub 2013 Apr 21.
4
Characteristics of CD44 alternative splice pattern in the course of human colorectal adenocarcinoma progression.CD44 剪接模式特征在人类结直肠腺癌进展过程中的作用。
Mol Cancer. 2012 Nov 14;11:83. doi: 10.1186/1476-4598-11-83.
5
Mac-2 binding protein is a novel E-selectin ligand expressed by breast cancer cells.巨噬细胞细胞黏附分子-2 结合蛋白是一种新型的乳腺癌细胞表达的 E-选择素配体。
PLoS One. 2012;7(9):e44529. doi: 10.1371/journal.pone.0044529. Epub 2012 Sep 6.
6
Three to Tango: MUC1 as a Ligand for Both E-Selectin and ICAM-1 in the Breast Cancer Metastatic Cascade.三向探戈：MUC1 作为乳腺癌转移级联中 E-选择素和 ICAM-1 的配体。
Front Oncol. 2012 Jul 27;2:76. doi: 10.3389/fonc.2012.00076. eCollection 2012.
7
Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers.选择素配体唾液酸化-Lewis x 抗原促进激素依赖性乳腺癌的转移。
Cancer Res. 2011 Dec 15;71(24):7683-93. doi: 10.1158/0008-5472.CAN-11-1139. Epub 2011 Oct 24.
8
Understanding the dual nature of CD44 in breast cancer progression.理解 CD44 在乳腺癌进展中的双重特性。
Mol Cancer Res. 2011 Dec;9(12):1573-86. doi: 10.1158/1541-7786.MCR-11-0156. Epub 2011 Oct 4.
9
CD44 and HCELL: preventing hematogenous metastasis at step 1.CD44 和 HCELL：在第一步阻止血行转移。
FEBS Lett. 2011 Oct 20;585(20):3148-58. doi: 10.1016/j.febslet.2011.07.039. Epub 2011 Aug 5.
10
The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives.CD44 和 HCELL 在造血中的生物学作用：“步骤 2 旁路途径”和其他新出现的观点。
Curr Opin Hematol. 2011 Jul;18(4):239-48. doi: 10.1097/MOH.0b013e3283476140.

在乳腺癌转移前生态位阻断黏附级联反应以预防转移。

Blocking the adhesion cascade at the premetastatic niche for prevention of breast cancer metastasis.

作者信息

Kang Shin-Ae, Hasan Nafis, Mann Aman P, Zheng Wei, Zhao Lichao, Morris Lynsie, Zhu Weizhu, Zhao Yan D, Suh K Stephen, Dooley William C, Volk David, Gorenstein David G, Cristofanilli Massimo, Rui Hallgeir, Tanaka Takemi

机构信息

Department of Pathology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Department of Pharmaceutical Sciences, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

出版信息

Mol Ther. 2015 Jun;23(6):1044-1054. doi: 10.1038/mt.2015.45. Epub 2015 Mar 27.

DOI:10.1038/mt.2015.45
PMID:25815697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4817749/
Abstract

Shear-resistant adhesion and extravasation of disseminated cancer cells at the target organ is a crucial step in hematogenous metastasis. We found that the vascular adhesion molecule E-selectin preferentially promoted the shear-resistant adhesion and transendothelial migration of the estrogen receptor (ER)(-)/CD44(+) hormone-independent breast cancer cells, but not of the ER(+)/CD44(-/low) hormone-dependent breast cancer cells. Coincidentally, CD44(+) breast cancer cells were abundant in metastatic lung and brain lesions in ER(-) breast cancer, suggesting that E-selectin supports hematogenous metastasis of ER(-)/CD44(+) breast cancer. In an attempt to prevent hematogenous metastasis through the inhibition of a shear-resistant adhesion of CD44(+) cancer cells to E-selectin-expressing blood vessels on the premetastatic niche, an E-selectin targeted aptamer (ESTA) was developed. We demonstrated that a single intravenous injection of ESTA reduced metastases to a baseline level in both syngeneic and xenogeneic forced breast cancer metastasis models without relocating the site of metastasis. The effect of ESTA was absent in E-selectin knockout mice, suggesting that E-selectin is a molecular target of ESTA. Our data highlight the potential application of an E-selectin antagonist for the prevention of hematogenous metastasis of ER(-)/CD44(+) breast cancer.

摘要

循环肿瘤细胞在靶器官处的抗剪切黏附及外渗是血行转移的关键步骤。我们发现血管黏附分子E-选择素优先促进雌激素受体（ER）（-）/CD44（+）激素非依赖性乳腺癌细胞的抗剪切黏附及跨内皮迁移，而对ER（+）/CD44（- /低）激素依赖性乳腺癌细胞则无此作用。巧合的是，CD44（+）乳腺癌细胞在ER（-）乳腺癌的肺和脑转移病灶中大量存在，提示E-选择素支持ER（-）/CD44（+）乳腺癌的血行转移。为了通过抑制CD44（+）癌细胞与转移前生态位上表达E-选择素的血管的抗剪切黏附来预防血行转移，我们开发了一种靶向E-选择素的适体（ESTA）。我们证明，在同基因和异种移植的强制乳腺癌转移模型中，单次静脉注射ESTA可将转移减少至基线水平，且不会改变转移部位。ESTA对E-选择素基因敲除小鼠无效，提示E-选择素是ESTA的分子靶点。我们的数据凸显了E-选择素拮抗剂在预防ER（-）/CD44（+）乳腺癌血行转移方面的潜在应用价值。