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[胶质细胞传递与脑功能]

[Gliaotransmission and brain functions].

作者信息

Koizumi Schuichi

出版信息

Nihon Shinkei Seishin Yakurigaku Zasshi. 2015 Feb;35(1):5-9.

Abstract

Glial cells receive neurotransmitters, respond to them, and then release so-called gliotransmitters such as ATP, glutamate or D-serine. Astrocytes in particular have received much attention because synaptic structures are surrounded by astrocytic fine processes, by which astrocytes communicate with neurons via gliotransmitters. Here, we introduce recent progress concerning glia-neuron interaction, especially focusing on the major gliotransmitter ATP and astrocytes in parallel with the latest progress in glia-imaging techniques.

摘要

神经胶质细胞接收神经递质,对其作出反应,然后释放诸如三磷酸腺苷(ATP)、谷氨酸或D-丝氨酸等所谓的神经胶质递质。尤其是星形胶质细胞受到了广泛关注,因为突触结构被星形胶质细胞的精细突起所包围,星形胶质细胞通过这些突起经由神经胶质递质与神经元进行交流。在此,我们介绍神经胶质细胞与神经元相互作用的最新进展,特别关注主要的神经胶质递质ATP和星形胶质细胞,同时介绍神经胶质成像技术的最新进展。

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