子痫前期中调节性T细胞亚型的患病率。
Prevalence of Regulatory T-Cell Subtypes in Preeclampsia.
作者信息
Toldi Gergely, Vásárhelyi Zsófia Eszter, Rigó János, Orbán Csaba, Tamássy Zita, Bajnok Anna, Shima Tomoko, Saito Shigeru, Molvarec Attila
机构信息
First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
出版信息
Am J Reprod Immunol. 2015 Aug;74(2):110-5. doi: 10.1111/aji.12380. Epub 2015 Mar 27.
PROBLEM
The prevalence of regulatory T cells (Tregs) is lower in preeclampsia (PE) compared with healthy pregnancy (HP). However, the proportion of recently described Treg subtypes has not been investigated.
METHOD
Peripheral blood samples of 19 PE and 21 HP women in the third trimester were evaluated using flow cytometry for the prevalence of activated T cells and naive, effector, thymic, extrathymic, and exhausted Tregs.
RESULTS
The prevalence of activated T cells and exhausted Tregs was higher in PE than in HP. The prevalence of the functionally most active effector Tregs is decreased, while naive Tregs appear to be unaffected in PE compared with HP. No difference was detected between Tregs according to their origin (thymic or extrathymic).
CONCLUSION
The combination of lower effector Treg and higher exhausted Treg prevalence may account for the decrease in the functionality of Tregs in PE.
问题
与正常妊娠（HP）相比，子痫前期（PE）中调节性T细胞（Tregs）的患病率较低。然而，最近描述的Treg亚型的比例尚未得到研究。
方法
使用流式细胞术评估19例PE和21例孕晚期HP女性外周血样本中活化T细胞以及幼稚、效应、胸腺来源、胸腺外来源和耗竭Tregs的患病率。
结果
PE中活化T细胞和耗竭Tregs的患病率高于HP。与HP相比，功能上最活跃的效应Tregs的患病率降低，而幼稚Tregs在PE中似乎未受影响。根据其来源（胸腺来源或胸腺外来源），Tregs之间未检测到差异。
结论
效应Tregs降低和耗竭Tregs患病率升高的组合可能是PE中Tregs功能下降的原因。
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