Fresa K L, Korngold R, Murasko D M
Cell Immunol. 1985 Apr 1;91(2):336-43. doi: 10.1016/0008-8749(85)90231-x.
Natural killer (NK) cell activity of thoracic duct lymphocytes (TDL) was examined in normal mice and in mice treated with polyinosinic-polycytidylic acid (poly(I:C) and interferon (IFN). TDL from mice treated with phosphate-buffered saline (PBS) expressed little or no NK cell activity against YAC-1 target cells at effector-to-target ratios of up to 200:1, even after in vitro treatment with murine L-cell IFN. In contrast, TDL from poly(I:C)- or IFN-treated mice expressed significant NK activity, which correlated with the significantly higher NK activity of splenocytes from these mice compared to the NK activity of splenocytes from PBS-treated mice. These data indicate that although TDL from normal mice express no detectable NK cell activity, NK cell activity can be induced in TDL by in vivo treatment with poly(I:C) or IFN.
在正常小鼠以及用聚肌苷酸-聚胞苷酸（poly(I:C)）和干扰素（IFN）处理过的小鼠中，检测了胸导管淋巴细胞（TDL）的自然杀伤（NK）细胞活性。用磷酸盐缓冲盐水（PBS）处理的小鼠的TDL，即使在体外用鼠L细胞IFN处理后，在效应细胞与靶细胞比例高达200:1时，对YAC-1靶细胞也几乎没有或没有NK细胞活性。相比之下，用poly(I:C)或IFN处理的小鼠的TDL表现出显著的NK活性，这与这些小鼠的脾细胞相比PBS处理小鼠的脾细胞显著更高的NK活性相关。这些数据表明，虽然正常小鼠的TDL不表现出可检测到的NK细胞活性，但通过体内用poly(I:C)或IFN处理可在TDL中诱导出NK细胞活性。
