博茨瓦纳人群中17个Y染色体短串联重复序列（Y-STR）位点的多态性。
Polymorphisms at 17 Y-STR loci in Botswana populations.
作者信息
Tau Tiroyamodimo, Davison Sean, D'Amato María Eugenia
机构信息
University of the Western Cape, Forensic DNA Laboratory, Private Bag X17, 7535 Bellville, Cape Town, South Africa.
University of the Western Cape, Forensic DNA Laboratory, Private Bag X17, 7535 Bellville, Cape Town, South Africa.
出版信息
Forensic Sci Int Genet. 2015 Jul;17:47-52. doi: 10.1016/j.fsigen.2015.03.001. Epub 2015 Mar 18.
Seventeen Y-chromosomal short tandem repeats (YSTRs)-DYS19, DYS389I, DYS389II, DYS385a/b, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, and Y-GATA-H4-were analyzed in 252 unrelated male individuals from Botswana. A total of 238 unique haplotypes were identified. The discrimination capacity (DC) was 0.9444 whereas the haplotype diversity (HD) was 0.9990. A database search of the 238 unique haplotypes in the Y chromosome haplogroup database (YHRD) yielded three African American, six Sub-Saharan African, and two admixed South American matches. Five additional African-American matches were detected in the Applied Biosystems Y-STR database. RST, multi-dimensional scaling (MDS) and AMOVA were used to investigate population differentiation in Sub-Saharan Africa and in Botswana. The populations in Sub-Saharan Africa were found to be heterogeneous, with Botswana showing significant differences from its neighbors. No geographic regional or ethnic differentiation was observed within Botswana. Regional and ethnic variation can be useful in forensic working hypotheses.
在来自博茨瓦纳的252名无亲缘关系的男性个体中，分析了17个Y染色体短串联重复序列（YSTRs）——DYS19、DYS389I、DYS389II、DYS385a/b、DYS390、DYS391、DYS392、DYS393、DYS437、DYS438、DYS439、DYS448、DYS456、DYS458、DYS635和Y-GATA-H4。共鉴定出238种独特的单倍型。鉴别能力（DC）为0.9444，而单倍型多样性（HD）为0.9990。在Y染色体单倍群数据库（YHRD）中对这238种独特单倍型进行数据库搜索，得到了3个非裔美国人、6个撒哈拉以南非洲人和2个混血南美人的匹配结果。在应用生物系统公司的Y-STR数据库中又检测到5个非裔美国人的匹配结果。使用RST、多维标度分析（MDS）和分子变异分析（AMOVA）来研究撒哈拉以南非洲和博茨瓦纳的群体分化。发现撒哈拉以南非洲的群体是异质的，博茨瓦纳与其邻国存在显著差异。在博茨瓦纳内部未观察到地理区域或种族分化。区域和种族变异在法医工作假设中可能有用。
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