McHugh Patrick C, Buckley David A
Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, United Kingdom.
Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, United Kingdom.
Vitam Horm. 2015;98:339-69. doi: 10.1016/bs.vh.2014.12.009. Epub 2015 Feb 14.
In this chapter, we explore the basic science of the dopamine transporter (DAT), an integral component of a system that regulates dopamine homeostasis. Dopamine is a key neurotransmitter for several brain functions including locomotor control and reward systems. The transporter structure, function, mechanism of action, localization, and distribution, in addition to gene regulation, are discussed. Over many years, a wealth of information concerning the DAT has been accrued and has led to increased interest in the role of the DAT in a plethora of central nervous system diseases. These DAT characteristics are explored in relation to a range of neurological and neuropsychiatric diseases, with a particular focus on the genetics of the DAT. In addition, we discuss the pharmacology of the DAT and how this relates to disease and addiction.
在本章中，我们将探讨多巴胺转运体（DAT）的基础科学，它是调节多巴胺稳态系统的一个重要组成部分。多巴胺是多种脑功能的关键神经递质，包括运动控制和奖赏系统。文中将讨论转运体的结构、功能、作用机制、定位和分布，以及基因调控。多年来，已经积累了大量关于DAT的信息，并引发了人们对DAT在众多中枢神经系统疾病中作用的更多关注。我们将探讨这些DAT特性与一系列神经和神经精神疾病的关系，特别关注DAT的遗传学。此外，我们还将讨论DAT的药理学及其与疾病和成瘾的关系。
