[原发性血小板增多症中的血栓形成事件及IPSET血栓形成风险评估评分的意义]

[Thrombotic events and significance of the IPSET thrombosis risk evaluation score in essential thrombocythaemia].

作者信息

Pósfai Éva, Marton Imelda, Nemes Attila, Borbényi Zita

机构信息

Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ, Általános Orvostudományi Kar II. Belgyógyászati Klinika és Kardiológiai Központ, Haematológiai Osztály Szeged.

Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ, Általános Orvostudományi Kar II. Belgyógyászati Klinika és Kardiológiai Központ Szeged Semmelweis utca 6. 6720.

出版信息

Orv Hetil. 2015 Apr 5;156(14):558-63. doi: 10.1556/OH.2015.30117.

DOI:10.1556/OH.2015.30117

PMID:25819149

Abstract

INTRODUCTION

Thrombo-haemorrhagic complications contribute to both morbidity and mortality in patients with essential thrombocythaemia.

AIM

The aim of the authors was to estimate the incidence of thrombotic events and to examine the clinical utility of IPSET thrombosis risk evaluation score against conventional two-categorical (low and high) risk assessment.

METHOD

A retrospective analysis was carried out on 155 patients with essential thrombocythaemia (106 females; median age, 61 years) in a period between 1999 and 2014.

RESULTS

The analysis revealed 55 (35.5%) major thrombotic events before and 25 (16.1%) major thrombotic complications after establishment of the haematologic diagnosis. Significant differences were observed in thrombosis-free survival between the different IPSET groups (p = 0.002).

CONCLUSIONS

The IPSET model was first examined in this cohort of patients with essential thrombocythaemia diagnosed in a single Hungarian haematologic centre. The results suggest that this score may provide more information than the conventional thrombosis risk assessment.

摘要