一种基于巨细胞病毒的疫苗单剂量接种后可对致死性埃博拉病毒攻击提供持久保护。
A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose.
作者信息
Tsuda Yoshimi, Parkins Christopher J, Caposio Patrizia, Feldmann Friederike, Botto Sara, Ball Susan, Messaoudi Ilhem, Cicin-Sain Luka, Feldmann Heinz, Jarvis Michael A
机构信息
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Vaccine and Gene Therapy Institute, Oregon Health & Sciences University, Portland, Oregon, USA.
出版信息
Vaccine. 2015 May 5;33(19):2261-2266. doi: 10.1016/j.vaccine.2015.03.029. Epub 2015 Mar 25.
Abstract
Ebola virus (Zaire ebolavirus; EBOV) is a highly lethal hemorrhagic disease virus that most recently was responsible for two independent 2014 outbreaks in multiple countries in Western Africa, and the Democratic Republic of the Congo, respectively. Herein, we show that a cytomegalovirus (CMV)-based vaccine provides durable protective immunity from Ebola virus following a single vaccine dose. This study has implications for human vaccination against ebolaviruses, as well as for development of a 'disseminating' vaccine to target these viruses in wild African great apes.
摘要
埃博拉病毒（扎伊尔埃博拉病毒；EBOV）是一种高度致命的出血热疾病病毒，最近分别在西非多个国家和刚果民主共和国引发了两次独立的2014年疫情。在此，我们表明，一种基于巨细胞病毒（CMV）的疫苗在单次接种后能提供持久的针对埃博拉病毒的保护性免疫。这项研究对人类埃博拉病毒疫苗接种以及开发一种针对野生非洲大猩猩体内这些病毒的“传播性”疫苗具有启示意义。
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