Wang Guanghua, Zheng Liang, Li Xiankai, Wu Juanli, Zhang Lijuan, Zhang Jie, Zou Liling, Li Xin, Zhang Yi, Zhou Qian, Fan Huimin, Li Yang, Li Jue
Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China.
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, 200120, China.
Sci Rep. 2015 Mar 30;5:9438. doi: 10.1038/srep09438.
The aim of this study is to investigate the viability of using brachial-ankle pulse wave velocity (baPWV) as a primary tool to screen metabolic syndrome (MetS), and to explore the risk factors of MetS in community populations. A total of 1914 subjects completed medical examination in Shanghai. BaPWV was significantly associated with the components of MetS. The area under curve (AUC) and its 95% confidence interval (CI) in total group were 62.50% and 60.00%-65.30% with the appropriate cut-off point being 1435 cm/sec. The AUC (95%CI) of three subgroups (40-50 yrs, 50-60 yrs and over 60 yrs group) were 75.30% (67.48%-83.35%), 63.35% (58.96%-67.60%), 55.37% (51.19%-60.01%), respectively. A clear pattern surfaced in the process of investigation: the younger were the subjects group, the better receiver operating characteristic (ROC) efficacy would emerge; and the higher sensitivity was, the better negative predictive value (NPV) would be. Male gender, high baPWV values, elevated uric acid (UA) and excess hypersensitive C reaction protein (hs-CRP) levels were stayed in the two regression models as the independent risk factors for MetS. We conclude that baPWV may serve as a potential screening tool for MetS at the cut-off point of 1435 cm/sec.
本研究旨在探讨使用肱踝脉搏波速度（baPWV）作为筛查代谢综合征（MetS）的主要工具的可行性，并探索社区人群中MetS的危险因素。共有1914名受试者在上海完成了体检。baPWV与MetS的各组分显著相关。总人群的曲线下面积（AUC）及其95%置信区间（CI）分别为62.50%和60.00%-65.30%，合适的截断点为1435 cm/秒。三个亚组（40-50岁、50-60岁和60岁以上组）的AUC（95%CI）分别为75.30%（67.48%-83.35%）、63.35%（58.96%-67.60%）、55.37%（51.19%-60.01%）。在调查过程中出现了一个明显的模式：受试者组越年轻，接收者操作特征（ROC）效能越好；敏感性越高，阴性预测值（NPV）越好。男性、高baPWV值、尿酸（UA）升高和超敏C反应蛋白（hs-CRP）水平升高在两个回归模型中作为MetS的独立危险因素保留。我们得出结论，在截断点为1435 cm/秒时，baPWV可能作为MetS的潜在筛查工具。
