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Lysis of anti-T3-bearing murine hybridoma cells by human allospecific cytotoxic T cell clones and inhibition of that lysis by anti-T3 and anti-LFA-1 antibodies.

作者信息

Hoffman R W, Bluestone J A, Leo O, Shaw S

出版信息

J Immunol. 1985 Jul;135(1):5-8.

PMID:2582047
Abstract
摘要

相似文献

1
Lysis of anti-T3-bearing murine hybridoma cells by human allospecific cytotoxic T cell clones and inhibition of that lysis by anti-T3 and anti-LFA-1 antibodies.人同种异体特异性细胞毒性T细胞克隆对携带抗T3的小鼠杂交瘤细胞的裂解作用以及抗T3和抗LFA-1抗体对该裂解作用的抑制。
J Immunol. 1985 Jul;135(1):5-8.
2
Anti-T3 antibody both activates and inhibits the cytotoxic activity of human T cell clones.抗T3抗体既能激活又能抑制人T细胞克隆的细胞毒性活性。
Behring Inst Mitt. 1985 Aug(77):30-8.
3
Susceptibility of cytotoxic T lymphocyte (CTL) clones to inhibition by anti-T3 and anti-T4 (but not anti-LFA-1) monoclonal antibodies varies with the "avidity" of CTL-target interaction.细胞毒性T淋巴细胞（CTL）克隆对抗T3和抗T4（而非抗LFA - 1）单克隆抗体抑制作用的敏感性随CTL与靶细胞相互作用的“亲和力”而变化。
J Immunol. 1985 May;134(5):3019-26.
4
Evidence for a regulatory role of the T8 (CD8) antigen in antigen-specific and anti-T3-(CD3)-induced lytic activity of allospecific cytotoxic T lymphocyte clones.T8（CD8）抗原在同种特异性细胞毒性T淋巴细胞克隆的抗原特异性及抗T3 -（CD3）诱导的裂解活性中起调节作用的证据。
Eur J Immunol. 1986 Nov;16(11):1363-71. doi: 10.1002/eji.1830161109.
5
T3 monoclonal antibody activation of nonspecific cytolysis: a mechanism of CTL inhibition.T3单克隆抗体激活非特异性细胞溶解：一种CTL抑制机制。
J Immunol. 1985 Jul;135(1):34-8.
6
Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies.单克隆抗-T3抗体诱导非特异性细胞毒性
J Immunol. 1985 Jun;134(6):3770-5.
7
Antigen-specific cytotoxic T cell and antigen-specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3.抗T3单克隆抗体可诱导抗原特异性细胞毒性T细胞和抗原特异性增殖性T细胞克隆产生溶细胞活性。
Eur J Immunol. 1985 Jan;15(1):88-91. doi: 10.1002/eji.1830150117.
8
A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among anti-Ia cytolytic T cell clones.一种大鼠抗小鼠T4单克隆抗体（H129.19）可抑制Ia反应性T细胞克隆的增殖，并在抗Ia细胞毒性T细胞克隆中区分出两个表型不同的亚群（T4+、Lyt-2,3-和T4-、Lyt-2,3+）。
J Immunol. 1984 Jun;132(6):2775-82.
9
Human lymphocyte function associated antigen-1 (LFA-1): identification of multiple antigenic epitopes and their relationship to CTL-mediated cytotoxicity.人淋巴细胞功能相关抗原-1（LFA-1）：多种抗原表位的鉴定及其与细胞毒性T淋巴细胞介导的细胞毒性的关系。
J Immunol. 1983 Sep;131(3):1182-8.
10
Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity.与自体黑色素瘤细胞反应的克隆化人细胞毒性T淋巴细胞（CTL）系。I. 体外生成、分离及表型和特异性分析。
J Immunol. 1984 Jan;132(1):510-9.

引用本文的文献

1
Bispecific antibodies retarget murine T cell cytotoxicity against syngeneic breast cancer in vitro and in vivo.双特异性抗体在体外和体内将小鼠T细胞细胞毒性重新导向同基因乳腺癌。
Cancer Immunol Immunother. 1995 Mar;40(3):182-90. doi: 10.1007/BF01517350.
2
Heteroantibody duplexes target cells for lysis by cytotoxic T lymphocytes.异源抗体双链体将细胞作为细胞毒性T淋巴细胞裂解的靶标。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8648-52. doi: 10.1073/pnas.82.24.8648.
3
Autologous tumor-specific cytotoxic T lymphocytes in the infiltrate of human metastatic melanomas. Activation by interleukin 2 and autologous tumor cells, and involvement of the T cell receptor.
人类转移性黑色素瘤浸润中的自体肿瘤特异性细胞毒性T淋巴细胞。白细胞介素2和自体肿瘤细胞的激活作用以及T细胞受体的参与。
J Exp Med. 1988 Oct 1;168(4):1419-41. doi: 10.1084/jem.168.4.1419.
4
Characterization of CD3+, CD4-, CD8- clones expressing the putative T cell receptor gamma gene product. Analysis of the activation pathways leading to interleukin 2 production and triggering of the lytic machinery.表达假定T细胞受体γ基因产物的CD3⁺、CD4⁻、CD8⁻克隆的特性分析。对导致白细胞介素2产生和触发裂解机制的激活途径的分析。
J Exp Med. 1987 Jul 1;166(1):277-82. doi: 10.1084/jem.166.1.277.
5
Activation of human peripheral blood mononuclear cells by anti-T3: killing of tumor target cells coated with anti-target-anti-T3 conjugates.抗T3激活人外周血单个核细胞：杀伤包被有抗靶标-抗T3偶联物的肿瘤靶细胞。
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4479-83. doi: 10.1073/pnas.83.12.4479.
6
Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity.T细胞抗原特异性受体的糖基化及其在凝集素介导的细胞毒性中的潜在作用。
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1852-6. doi: 10.1073/pnas.83.6.1852.
7
Specific targeting of human peripheral blood T cells by heteroaggregates containing anti-T3 crosslinked to anti-target cell antibodies.通过将抗T3与抗靶细胞抗体交联形成的异聚体对人外周血T细胞进行特异性靶向。
J Exp Med. 1986 Jan 1;163(1):166-78. doi: 10.1084/jem.163.1.166.
8
Alterations in cytotoxic and helper T cell function after infection of T cell clones with human T cell leukemia virus, type I.I型人类T细胞白血病病毒感染T细胞克隆后细胞毒性和辅助性T细胞功能的改变
J Clin Invest. 1986 May;77(5):1466-73. doi: 10.1172/JCI112459.
9
Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor.通过针对该受体两种不同分子形式的单克隆抗体，可以识别出表达γ/δ抗原受体的两类人T淋巴细胞亚群。
J Exp Med. 1988 Aug 1;168(2):491-505. doi: 10.1084/jem.168.2.491.
10
Identification of a monoclonal antibody specific for a murine T3 polypeptide.一种针对小鼠T3多肽的单克隆抗体的鉴定。
Proc Natl Acad Sci U S A. 1987 Mar;84(5):1374-8. doi: 10.1073/pnas.84.5.1374.