Peyronnet Benoit, Oger Emmanuel, Khene Zineddine, Verhoest Gregory, Mathieu Romain, Roumiguié Mathieu, Beauval Jean-Baptiste, Pradere Benjamin, Masson-Lecomte Alexandra, Vaessen Christophe, Baumert Hervé, Bernhard Jean-Christophe, Doumerc Nicolas, Droupy Stéphane, Bruyere Franck, De La Taille Alexandre, Roupret Morgan, Bensalah Karim
Department of Urology, University of Rennes, 2 rue Henri Le Guilloux, 35000, Rennes, France.
Department of Statistics, University of Rennes, Rennes, France.
World J Urol. 2015 Nov;33(11):1815-20. doi: 10.1007/s00345-015-1537-0. Epub 2015 Mar 29.
To assess the impact of HA on robotic PN (RPN) outcomes.
We retrospectively analyzed data from patients who underwent RPN in eight centers between 2009 and 2013. Hemorrhagic complications were defined as the occurrence of a pseudoaneurysm, arteriovenous fistula or hematoma requiring transfusion. Patients were first divided into two groups: group A (use of at least one HA) and group B (no HA used), and then into five groups to assess the impact of each HA: group 1 (no HA), group 2 (Floseal(®) only), group 3 (Surgicel(®) only), group 4 (Tachosil(®) only) and group 5 (Surgicel(®) + Floseal(®)). The impact of HA was evaluated by univariate and multivariate analysis.
Out of 515 RPN, 315 (61 %) were done using at least one HA (group A) and 200 (39 %) were done without any HA (group B). Patients in both groups had similar hemorrhagic complication rates (13 % vs. 15 %, p = 0.42) and postoperative complication rates (19 % vs. 23 %, p = 0.32). In multivariate analysis, the absence of HA was not a risk factor for hemorrhagic complications (OR 0.77, p = 0.54). When each type of HA was considered individually, none was associated with the occurrence of hemorrhagic complication either in univariate or in multivariate analysis.
In this multicenter study, the use of HA was not associated with a lower risk of hemorrhagic or global complications.
评估透明质酸(HA)对机器人辅助肾部分切除术(RPN)疗效的影响。
我们回顾性分析了2009年至2013年间在八个中心接受RPN治疗的患者数据。出血性并发症定义为出现假性动脉瘤、动静脉瘘或需要输血的血肿。患者首先被分为两组:A组(使用至少一种HA)和B组(未使用HA),然后再分为五组以评估每种HA的影响:第1组(未使用HA)、第2组(仅使用Floseal®)、第3组(仅使用Surgicel®)、第4组(仅使用Tachosil®)和第5组(Surgicel® + Floseal®)。通过单因素和多因素分析评估HA的影响。
在515例RPN手术中,315例(61%)至少使用了一种HA(A组),200例(39%)未使用任何HA(B组)。两组患者的出血性并发症发生率相似(13%对15%,p = 0.42),术后并发症发生率也相似(19%对23%,p = 0.3