Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Ann Surg. 2010 Feb;251(2):217-28. doi: 10.1097/SLA.0b013e3181c3bcca.
Since ancient times we have attempted to facilitate hemostasis by application of topical agents. In the last decade, the number of different effective hemostatic agents has increased drastically. In order for the modern surgeon to successfully choose the right agent at the right time, it is essential to understand the mechanism of action, efficacy and possible adverse events as they relate to each agent. In this article we provide a comprehensive review of the most commonly used hemostatic agents, subcategorized as physical agents, absorbable agents, biologic agents, and synthetic agents. We also evaluate novel hemostatic dressings and their application in the current era. Furthermore, wholesale acquisition prices for hospitals in the United States are provided to aid in cost analysis. We conclude with an expert opinion on which agent to use under different scenarios.
自古以来，我们一直试图通过应用局部制剂来促进止血。在过去的十年中，不同有效止血剂的数量急剧增加。为了让现代外科医生能够在正确的时间成功选择正确的药物，了解每种药物的作用机制、疗效和可能的不良反应是至关重要的。在本文中，我们全面回顾了最常用的止血剂，分为物理制剂、可吸收制剂、生物制剂和合成制剂。我们还评估了新型止血敷料及其在当前时代的应用。此外，还提供了美国医院的批发采购价格，以帮助进行成本分析。最后，我们根据不同情况给出了使用哪种药物的专家意见。
