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下肢巨大骨肿瘤切除术后的皮质支撑骨移植及长柄假体重建

Cortical strut bone grafting and long-stem endoprosthetic reconstruction following massive bone tumour resection in the lower limb.

作者信息

Qu H, Guo W, Yang R, Tang X, Yan T, Li D, Yang Y, Zang J

机构信息

People's Hospital, Peking University, Xizhimen Nan 11, Xicheng District, Beijing, 100044, China.

出版信息

Bone Joint J. 2015 Apr;97-B(4):544-9. doi: 10.1302/0301-620X.97B4.34695.

Abstract

We determined the efficacy of a devitalised autograft (n = 13) and allograft (n = 16) cortical strut bone graft combined with long-stem endoprosthetic reconstruction in the treatment of massive tumours of the lower limb. A total of 29 patients (18 men:11 women, mean age 20.1 years (12 to 45) with a ratio of length of resection to that of the whole prosthesis of > 50% were treated between May 2003 and May 2012. The mean follow-up was 47 months (15 to 132). The stem of the prosthesis was introduced through bone graft struts filled with cement, then cemented into the residual bone. Bone healing was achieved in 23 patients (86%). The mean Musculoskeletal Tumour Society functional score was 85% (57 to 97). The five-year survival rate of the endoprostheses was 81% (95% confidence intervals 67.3 to 92.3). The mean length of devitalised autografts and allografts was 8.6 cm (5 to 15), which increased the ratio of the the length of the stem of the prosthesis to that of the whole length of the prosthesis from a theoretical 35% to an actual 55%. Cortical strut bone grafting and long-stem endoprosthetic reconstruction is an option for treating massive segmental defects following resection of a tumour in the lower limb. Patients can regain good function with a low incidence of aseptic loosening. The strut graft and the residual bone together serve as a satisfactory bony environment for a revision prosthesis, if required, once union is achieved.

摘要

我们确定了失活自体骨移植(n = 13)和同种异体骨移植(n = 16)皮质支撑骨移植联合长柄假体重建在治疗下肢巨大肿瘤中的疗效。2003年5月至2012年5月期间,共治疗了29例患者(18例男性:11例女性,平均年龄20.1岁(12至45岁)),切除长度与整个假体长度之比> 50%。平均随访时间为47个月(15至132个月)。假体柄通过填充骨水泥的骨移植支撑物插入,然后用骨水泥固定在残余骨中。23例患者(86%)实现了骨愈合。肌肉骨骼肿瘤学会功能评分平均为85%(57至97)。假体的五年生存率为81%(95%置信区间67.3至92.3)。失活自体骨移植和同种异体骨移植的平均长度为8.6 cm(5至15 cm),这将假体柄长度与整个假体长度的比例从理论上的35%提高到了实际的55%。皮质支撑骨移植和长柄假体重建是治疗下肢肿瘤切除后巨大节段性缺损的一种选择。患者可以恢复良好的功能,无菌性松动发生率低。如果需要,一旦实现骨愈合,支撑骨移植和残余骨共同为翻修假体提供了令人满意的骨环境。

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