苯噻啶对钙通道的拮抗作用。
Calcium channel antagonism by pizotifen.
作者信息
Peroutka S J, Banghart S B, Allen G S
出版信息
J Neurol Neurosurg Psychiatry. 1985 Apr;48(4):381-3. doi: 10.1136/jnnp.48.4.381.
Abstract
Pizotifen is a clinically effective anti-migraine agent with potent anti-serotonin and anti-histamine properties. Pizotifen is equipotent in blocking contractions of the canine basilar artery induced by serotonin, norepinephrine or calcium chloride. As a result, the primary action of pizotifen in the canine basilar artery system appears to be calcium channel blockade and not selective antagonism of serotonin or norepinephrine. Calcium channel blocking ability may be related to the clinical efficacy of pizotifen in the treatment of migraine.
摘要
苯噻啶是一种临床有效的抗偏头痛药物，具有强大的抗血清素和抗组胺特性。苯噻啶在阻断血清素、去甲肾上腺素或氯化钙诱导的犬基底动脉收缩方面具有同等效力。因此，苯噻啶在犬基底动脉系统中的主要作用似乎是钙通道阻滞，而不是对血清素或去甲肾上腺素的选择性拮抗。钙通道阻断能力可能与苯噻啶治疗偏头痛的临床疗效有关。
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