Suzuki Y, Ohshika H
Jpn J Pharmacol. 1985 Feb;37(2):212-4. doi: 10.1254/jjp.37.212.
The present study was carried out to determine the relationship of beta 1- and Beta 2-subtype to amylase release and cyclic AMP (cAMP) accumulation in rat parotid tissue. In in vitro experiments, beta-adrenergic agents (isoproterenol and dobutamine)-induced amylase release and cAMP accumulation were all completely inhibited by the beta 1-antagonist metoprolol, but incompletely inhibited by the beta 2-antagonist butoxamine. The beta 2-agonist procaterol caused little or no amylase release or cAMP accumulation. Our results suggest that both amylase release and cAMP accumulation in rat parotid tissue may be selectively induced by beta 1-adrenergic stimulation.
本研究旨在确定β1和β2亚型与大鼠腮腺组织中淀粉酶释放及环磷酸腺苷（cAMP）积累之间的关系。在体外实验中，β肾上腺素能药物（异丙肾上腺素和多巴酚丁胺）诱导的淀粉酶释放及cAMP积累均被β1拮抗剂美托洛尔完全抑制，但仅被β2拮抗剂布托沙明不完全抑制。β2激动剂丙卡特罗几乎不引起淀粉酶释放或cAMP积累。我们的结果表明，大鼠腮腺组织中的淀粉酶释放及cAMP积累可能均由β1肾上腺素能刺激选择性诱导。
