进行性系统性硬化症中纤维蛋白溶解抑制剂的扰动
Perturbation of fibrinolysis inhibitors in progressive systemic sclerosis.
作者信息
Rothschild B, Thompson L D, Chesney M, Pifer D
出版信息
Med Hypotheses. 1985 Mar;16(3):253-60. doi: 10.1016/0306-9877(85)90007-6.
Significance of fibrinolysis in pathophysiology of progressive systemic sclerosis (PSS) has been the subject of much speculation. Renal disease in PSS was associated with significant depression of an inhibitor of fibrinolysis, antithrombin III (ATIII), independent of general disease activity. Association of ATIII depression with plasminogen consumption supports an active role for plasmin or another ATIII-inhibitable enzyme in the pathophysiology of renal disease in PSS, and may explain the thrombotic tendency and propensity for fibrin deposition.
纤维蛋白溶解在进行性系统性硬化症（PSS）病理生理学中的意义一直是诸多猜测的主题。PSS中的肾脏疾病与纤维蛋白溶解抑制剂抗凝血酶III（ATIII）的显著降低有关，且与总体疾病活动无关。ATIII降低与纤溶酶原消耗之间的关联支持了纤溶酶或另一种可被ATIII抑制的酶在PSS肾脏疾病病理生理学中发挥积极作用，并且可能解释了血栓形成倾向和纤维蛋白沉积的易感性。
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