Joy R M, Albertson T E
Neurobehav Toxicol Teratol. 1985 Jan-Feb;7(1):1-8.
Lindane, 10 mg/kg, IP in DMSO, was administered to rats implanted with electrodes to stimulate the perforant path and record from the dentate gyrus of the hippocampal formation. Dentate responses were examined in acutely prepared, anesthetized rats and chronically prepared rats in unanesthetized and anesthetized states. The most significant and reliable effect of lindane administration was to increase the number of granule cells excited to discharge in response to perforant path stimulation. Further analysis indicated that lindane did not appear to produce this action by increasing transmitter release from the perforant path terminals. The primary site of action was the granule cell itself. Inhibition, mediated by recurrent collaterals and believed to be GABA-mediated, was not reduced and, in some circumstances, was increased after lindane administration. These data suggest that the primary action of lindane in intact subjects is to increase neuronal excitability. Enhanced transmitter release or reduction in GABA-mediated inhibition could not be demonstrated to contribute significantly to this effect.
将10毫克/千克林丹溶于二甲基亚砜中，经腹腔注射给予植入电极的大鼠，以刺激穿通通路并记录海马结构齿状回的活动。在急性制备的麻醉大鼠以及处于未麻醉和麻醉状态的慢性制备大鼠中检测齿状回的反应。给予林丹后最显著且可靠的效应是增加了因穿通通路刺激而激发放电的颗粒细胞数量。进一步分析表明，林丹似乎并非通过增加穿通通路终末的递质释放来产生这一作用。主要作用部位是颗粒细胞本身。由回返侧支介导且被认为是由γ-氨基丁酸介导的抑制作用并未减弱，在某些情况下，给予林丹后反而增强。这些数据表明，林丹在完整动物体内的主要作用是增加神经元兴奋性。增强的递质释放或γ-氨基丁酸介导的抑制作用减弱并不能被证明对这一效应有显著贡献。
