Shawana Summayya, Kehar Shahnaz Imdad, Shaikh Fouzia
J Pak Med Assoc. 2014 Oct;64(10):1103-8.
To observe the differential expression of phophatase and tensin homologue in normal proliferative, hyperplastic and malignant endometrial lesions.
.The retrospective study was based on the analysis of endometrial samples, both hysterectomies and curettage, received at the department of pathology Basic Medical Sciences Institute at the Jinnah Postgraduate Medical Centre, Karachi, from January 1, 2006 to December 31, 2010. A total of 55 endometrial samples were analysed for morphological features and results of immunohistochemical staining.
Of the 55 samples, 25 (45.45%) were malignant endometrial lesions, 6 (10.9%) complex hyperplasias with atypia, 14(25.45%) complex hyperplasias without atypia hyperplasia, 6 (10.9%) simple hyperplasias without atypia, and 4 (7.27%) normal proliferative endometrium. Among malignant endometrial lesions, 12 (48%) showed complete loss of phophotase and tensin homologue expression out of which majority were endometroid adenocarcinoma. Five (83.3%) cases of complex hyperplasias with atypia and 9 (64.28%) cases of complex hyperplasia without atypia showed complete loss of or diminished expression of phophotase and tensin homologue.
Loss of phophotase and tensin homologue expression was seen in a significant number of well differentiated endometrial adenocarcinomas and complex hyperplasias with atypia suggesting loss of PTEN expression as an early event in endometrial carcinogenesis.
观察磷酸酶和张力蛋白同源物在正常增殖期、增生期及恶性子宫内膜病变中的差异表达。
本回顾性研究基于对2006年1月1日至2010年12月31日在卡拉奇真纳研究生医学中心基础医学科学研究所病理科接收的子宫内膜样本（包括子宫切除术和刮宫术样本）的分析。共对55份子宫内膜样本进行了形态学特征分析和免疫组化染色结果分析。
在55份样本中，25份（45.45%）为恶性子宫内膜病变，6份（10.9%）为复杂性非典型增生，14份（25.45%）为复杂性非非典型增生，6份（10.9%）为单纯性非非典型增生，4份（7.27%）为正常增殖期子宫内膜。在恶性子宫内膜病变中，12份（48%）显示磷酸酶和张力蛋白同源物表达完全缺失，其中大多数为子宫内膜样腺癌。5份（83.3%）复杂性非典型增生病例和9份（64.28%）复杂性非非典型增生病例显示磷酸酶和张力蛋白同源物表达完全缺失或减弱。
在大量高分化子宫内膜腺癌和复杂性非典型增生中可见磷酸酶和张力蛋白同源物表达缺失，提示PTEN表达缺失是子宫内膜癌发生的早期事件。
