Sheikh Ali Sibtain Farooq, Sheikh Saman Ali, Mohamed Mona Adel
J Pak Med Assoc. 2014 Oct;64(10):1179-85.
In this paper, we have collected the findings of available literature focusing on brain metabolites by spectroscopy in the murine model of cerebral malaria disease. The literature search for experimental cerebral malaria (ECM) and spectroscopy using National Institute of Health's PubMed database provided us with 9 peer-reviewed publications. These publications have used mice infected with Plasmodium Berghei (PbA) Antwerpen-Kasapa (ANKA) strain to mimic the human infection with Plasmodium falciparum. Brain ischaemia, as depicted by increased lactate and alanine concentrations, as well as decreased aspartate and adenosine triphosphate levels, play a key role in ECM. Lowering the lactate levels by using dichloroacetate has been shown to improve survival. Significant cellular injury has also been documented through decreased N-acetylaspartate and glycerophosphocholine levels. The advantage of using spectroscopic technique provide important functional information which helps determine the aetiology, pathogenesis, progression, and monitoring of treatment as well as predicting prognosis in the clinical setting of cerebral malaria.
在本文中，我们收集了通过光谱学研究脑疟疾疾病小鼠模型中脑代谢物的现有文献的研究结果。使用美国国立卫生研究院的PubMed数据库对实验性脑疟疾（ECM）和光谱学进行文献检索，为我们提供了9篇同行评审的出版物。这些出版物使用感染了伯氏疟原虫（PbA）安特卫普-卡萨帕（ANKA）株的小鼠来模拟人类感染恶性疟原虫的情况。脑缺血，表现为乳酸和丙氨酸浓度升高以及天冬氨酸和三磷酸腺苷水平降低，在ECM中起关键作用。已证明使用二氯乙酸降低乳酸水平可提高生存率。通过降低N-乙酰天门冬氨酸和甘油磷酸胆碱水平也记录到了显著的细胞损伤。使用光谱技术的优势在于提供重要的功能信息，有助于确定脑疟疾临床环境中的病因、发病机制、进展、治疗监测以及预测预后。
