Najam Syeda Sadia, Awan Fazli Rabbi, Baig Shahid Mahmood
J Pak Med Assoc. 2014 Oct;64(10):1186-8.
Adiponectin has been associated with common metabolic disorders. The current study was conducted to measure and compare levels of adiponectin with obesity, type 2 diabetes mellitus (T2DM) and gender in Punjabi subjects from Faisalabad, Pakistan. Serum adiponectin was measured by enzyme-linked immunosorbent assay (ELISA) along with measurements of some clinically important analytes (fasting blood glucose, cholesterol, triglycerides) as well as body mass index (BMI) in 80 subjects. The main results were significantly (p < 0.003) decreased serum adiponectin level in T2DM patients (n = 40) compared to non-diabetic controls (n = 40). In obese subjects, (n = 40) also, there was a decrease, but it was not significant. Adiponectin levels in the subgroups of diabetic and obese patients were also observed, but no significant gender-based differences were found.
脂联素与常见的代谢紊乱有关。本研究旨在测量并比较巴基斯坦费萨拉巴德地区旁遮普族受试者中脂联素水平与肥胖、2型糖尿病（T2DM）及性别的关系。采用酶联免疫吸附测定法（ELISA）对80名受试者的血清脂联素进行检测，并同时测量一些临床重要分析物（空腹血糖、胆固醇、甘油三酯）以及体重指数（BMI）。主要结果显示，与非糖尿病对照组（n = 40）相比，T2DM患者（n = 40）的血清脂联素水平显著降低（p < 0.003）。在肥胖受试者（n = 40）中，脂联素水平也有所下降，但不显著。研究还观察了糖尿病和肥胖患者亚组中的脂联素水平，但未发现基于性别的显著差异。
