Hypoglycaemia is perhaps the most common complication of diabetes management. Often fatal, this condition can easily be prevented and managed. This paper reviews recent advances in understanding the causes of iatrogenic hypoglycaemia in diabetes, and the clinical risk factors associated with it. It provides a simple framework to help classify and asses these causative and risk factors. Also discussed are relevant non- pharmacological and pharmacological strategies to help prevent and manage hypoglycaemia.