Lan Chen-Chia, Liu Chia-Chien, Chen Ying-Sheue
Department of Psychiatry, Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan, ROC.
Department of Psychiatry, National Yang-Ming University Hospital, Yilan, Taiwan, ROC.
J Chin Med Assoc. 2015 Jun;78(6):374-6. doi: 10.1016/j.jcma.2014.05.017. Epub 2015 Mar 29.
Influenza treatment and prophylaxis with oseltamivir are critically important in reducing the morbidity and mortality of patients in chronic psychiatric facilities. Abnormal behavior, delusions, perceptual disturbances, mania, and depression have all been reported as oseltamivir-related psychiatric side effects. We hereby report two chronic schizophrenia patients in Taiwan manifesting psychiatric instability who were being treated with oseltamivir for suspected influenza infection, and further discuss other potential contributing factors. The possibility that oseltamivir can cause psychotic or affective symptoms suggests that additional caution is necessary for its use in patients with an established psychiatric diagnosis.
使用奥司他韦进行流感治疗和预防对于降低慢性精神病设施中患者的发病率和死亡率至关重要。异常行为、妄想、感知障碍、躁狂和抑郁均已被报告为奥司他韦相关的精神副作用。我们在此报告台湾地区两名患有慢性精神分裂症且表现出精神状态不稳定的患者，他们因疑似流感感染而接受奥司他韦治疗，并进一步讨论其他潜在的促成因素。奥司他韦可能导致精神病性或情感症状这一可能性表明，对于已确诊患有精神疾病的患者使用该药时需要格外谨慎。
