中国四川省现住居民1629例新诊断恶性淋巴瘤的临床分析
Clinical analysis of 1629 newly diagnosed malignant lymphomas in current residents of Sichuan province, China.
作者信息
Wang Xue-Mei, Bassig Bryan A, Wen Jing-Jing, Li Gan-di, Liu Zhi-Bin, Yao Wen-Xiu, Hu Wei, Wang Ying, Li Ji-Man, Wang Xiao-Dong, Gan Mao-Zhou, Wang Chun-Sen, Xu Gang, Rothman Nathaniel, Lan Qing, Xu Cai-Gang
机构信息
Department of Hematology, Hematology Research Laboratory and Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
出版信息
Hematol Oncol. 2016 Dec;34(4):193-199. doi: 10.1002/hon.2202. Epub 2015 Mar 30.
Previous studies in other provinces of China (Beijing, Xinjiang, Shanxi, Jiangxi, Shanghai, Guangdong, and Taiwan) suggest that the distributions of lymphoma subtypes differ compared with Western populations. In order to evaluate the characteristics of malignant lymphoma in Sichuan, China, we analyzed case series data from incident lymphoma patients diagnosed in 2008 from three hospitals, including a total of 1629 cases and including only current residents of Sichuan. The median age of diagnosis for cases was 54 years, with a higher proportion of male cases compared with female cases. The most commonly diagnosed subtypes included diffuse large B-cell lymphoma (40.4%), NK/T-cell lymphoma (NKTCL; 11.8%), mixed cellularity Hodgkin lymphoma (7.0%), mantle cell lymphoma (4.8%), and marginal zone B-cell lymphoma (3.9%). Differences in demographic characteristics between Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) cases were apparent for median age at diagnosis (HL: 34 years; NHL: 57 years), and NHLs accounted for nearly all (99.3%) of the 931 cases of extranodal lymphoma. These findings indicate a higher proportion of NKTCL cases and a lower proportion of follicular lymphoma cases (2.3%) in these hospitals in Sichuan, relative to reports from some other provinces within China (e.g., Shanghai and Shanxi) and the USA. Copyright © 2015 John Wiley & Sons, Ltd.
此前在中国其他省份(北京、新疆、山西、江西、上海、广东和台湾)开展的研究表明,与西方人群相比,淋巴瘤亚型的分布有所不同。为了评估中国四川恶性淋巴瘤的特征,我们分析了2008年在三家医院确诊的新发淋巴瘤患者的病例系列数据,共1629例,且仅纳入四川本地居民。病例的诊断中位年龄为54岁,男性病例的比例高于女性病例。最常诊断的亚型包括弥漫性大B细胞淋巴瘤(40.4%)、NK/T细胞淋巴瘤(NKTCL;11.8%)、混合细胞型霍奇金淋巴瘤(7.0%)、套细胞淋巴瘤(4.8%)和边缘区B细胞淋巴瘤(3.9%)。霍奇金淋巴瘤(HL)和非霍奇金淋巴瘤(NHL)病例在诊断中位年龄方面的人口统计学特征差异明显(HL:34岁;NHL:57岁),在931例结外淋巴瘤病例中,NHL占了几乎所有病例(99.3%)。这些研究结果表明,相对于中国其他一些省份(如上海和山西)以及美国的报告,四川这些医院中NKTCL病例的比例较高,而滤泡性淋巴瘤病例的比例较低(2.3%)。版权所有© 2015约翰·威利父子有限公司。
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