The addition of CD20 monoclonal antibodies to lenalidomide improves response rates and survival in relapsed/refractory patients with chronic lymphocytic leukaemia relative to lenalidomide monotherapy - the MD Anderson Cancer Center experience.
作者信息
Thompson Philip A, Rozovski Uri, Keating Michael J, Stingo Francesco, Smith Susan C, Wierda William G, Falchi Lorenzo, O'Brien Susan M, Estrov Zeev, Burger Jan A, Ferrajoli Alessandra
机构信息
Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.
Department of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Br J Haematol. 2015 Oct;171(2):281-284. doi: 10.1111/bjh.13377. Epub 2015 Mar 30.
Abstract
摘要
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The addition of CD20 monoclonal antibodies to lenalidomide improves response rates and survival in relapsed/refractory patients with chronic lymphocytic leukaemia relative to lenalidomide monotherapy - the MD Anderson Cancer Center experience.与来那度胺单药治疗相比，在来那度胺基础上加用CD20单克隆抗体可提高复发/难治性慢性淋巴细胞白血病患者的缓解率并延长生存期——MD安德森癌症中心的经验。
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Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions.奥滨尤妥珠单抗联合苯丁酸氮芥治疗伴有合并症的 CLL 患者。
N Engl J Med. 2014 Mar 20;370(12):1101-10. doi: 10.1056/NEJMoa1313984. Epub 2014 Jan 8.
2
Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia.来那度胺可诱导老年慢性淋巴细胞白血病患者产生持久缓解。
Blood. 2013 Aug 1;122(5):734-7. doi: 10.1182/blood-2013-04-495341. Epub 2013 Jun 25.
3
Phase II study of lenalidomide and rituximab as salvage therapy for patients with relapsed or refractory chronic lymphocytic leukemia.来那度胺和利妥昔单抗作为挽救疗法治疗复发或难治性慢性淋巴细胞白血病患者的 II 期研究。
J Clin Oncol. 2013 Feb 10;31(5):584-91. doi: 10.1200/JCO.2012.42.8623. Epub 2012 Dec 26.
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Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma.利用合成致死性治疗 ABC 弥漫性大 B 细胞淋巴瘤。
Cancer Cell. 2012 Jun 12;21(6):723-37. doi: 10.1016/j.ccr.2012.05.024.
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Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia.来那度胺作为老年慢性淋巴细胞白血病患者的初始治疗。
Blood. 2011 Sep 29;118(13):3489-98. doi: 10.1182/blood-2011-03-339077. Epub 2011 Jul 1.
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Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia.来那度胺单药治疗未经治疗的慢性淋巴细胞白血病。
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lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells.来那度胺增强利妥昔单抗治疗的CD20+肿瘤细胞的自然杀伤细胞和单核细胞介导的抗体依赖性细胞毒性。
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Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia.来那度胺可使复发难治性慢性淋巴细胞白血病患者获得完全缓解和部分缓解。
Blood. 2008 Jun 1;111(11):5291-7. doi: 10.1182/blood-2007-12-130120. Epub 2008 Mar 11.
9
Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study.来那度胺治疗复发或难治性慢性淋巴细胞白血病患者的临床疗效：一项II期研究结果
J Clin Oncol. 2006 Dec 1;24(34):5343-9. doi: 10.1200/JCO.2005.05.0401. Epub 2006 Nov 6.
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