Janata V, Stríbrná J
Cas Lek Cesk. 1989 Sep 29;128(40):1261-4.
The authors investigated in 20 healthy normotonics changes of the blood pressure and sodium transport in red cells after two dietary regimes: I. normal diet, II. normal diet + 5 g salt/day for a period of 7 days. After the salt load the following changes were observed: 1. a rise of the pressure and body weight 2. an increase of the mean blood pressure (MBP) by more than 7% in 11 subjects, described as "salt sensitive" (SS), the remaining 9 were not sensitive to salt (NSS); 3. a significant activation of ouabain sensitive transport (Na pump) in NSS. The authors did not observe a reduced activity of the Na pump found in volume expansion in essential hypertonics. On the other hand, after the salt load in normotonics an adaptive increase of the Na pump activation occurred which, however, was not sufficient in VSS normotonics. The authors assume that an inadequate response of the Na pump to a salt load in SS may be due to structural changes of the pump or its inadequate functional reserve which may be genetically conditioned and may lead secondarily to an increased salt sensitivity.
作者对20名健康的血压正常者在两种饮食方案后红细胞中的血压和钠转运变化进行了研究：方案一，正常饮食；方案二，正常饮食 + 每天5克盐，持续7天。在盐负荷后观察到以下变化：1. 血压和体重升高；2. 11名受试者的平均血压（MBP）升高超过7%，这些受试者被描述为“盐敏感型”（SS），其余9名对盐不敏感（NSS）；3. NSS中哇巴因敏感转运（钠泵）显著激活。作者未观察到原发性高血压患者容量扩张时出现的钠泵活性降低。另一方面，在血压正常者盐负荷后，钠泵激活出现适应性增加，然而，在盐敏感型血压正常者中这种增加并不充分。作者认为，盐敏感型患者中钠泵对盐负荷反应不足可能是由于泵的结构变化或其功能储备不足，这可能是由基因决定的，继而可能导致盐敏感性增加。
