RASSF1A基因甲基化与中国人群鼻咽癌风险相关。
RASSF1A gene methylation is associated with nasopharyngeal carcinoma risk in Chinese.
作者信息
Wu Kun, Xu Xiao-Ning, Chen Yu, Pu Xiao-Lin, Wang Bo-Yuan, Tang Xiao-Dan
机构信息
Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan, P.R. China E-mail :
出版信息
Asian Pac J Cancer Prev. 2015;16(6):2283-7. doi: 10.7314/apjcp.2015.16.6.2283.
In order to explore the association between RASSF1A methylation and nasopharyngeal carcinoma (NPC) risk of Chinese, we carried out a meta-analysis with searches of PubMed, Web of Science, ProQest and Medline databases. Ultimately, 14 articles were identified and analysised using R Software (R version 3.1.2) including meta packages. Overall, we found a significant relationship between RASSF1A methylation and NPC risk (OR 30.7; 95 % CI, 16.7156.23; z=11.0591; p<0.0001) in a fixed effects model and (OR 32.1; 95% CI, 14.2772.01; z=8.3984; p<0.0001) in a random effects model pooled. In tissue and NP brushings groups , similar results were found. Hence, our study identified a strong association between RASSF1A methylation and NPC and highlighted a promising potential for RASSF1A methylation in NPC risk prediction of Chinese.
为了探究RASSF1A甲基化与中国人鼻咽癌（NPC）风险之间的关联，我们对PubMed、Web of Science、ProQest和Medline数据库进行检索，开展了一项荟萃分析。最终，使用包括meta包在内的R软件（R版本3.1.2）对14篇文章进行了识别和分析。总体而言，在固定效应模型中，我们发现RASSF1A甲基化与NPC风险之间存在显著关联（比值比30.7；95%置信区间，16.7156.23；z=11.0591；p<0.0001），在随机效应模型合并分析中（比值比32.1；95%置信区间，14.2772.01；z=8.3984；p<0.0001）。在组织和鼻咽刷检组中也发现了类似结果。因此，我们的研究确定了RASSF1A甲基化与NPC之间存在强关联，并突出了RASSF1A甲基化在中国人NPC风险预测中的潜在前景。
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